Cannabis Use
Conditions
Brief summary
The use of Cannabis is increasing in the population, and the effects that this might have on different medical procedures are poorly understood. Particularly when submitted to deep sedation or general anesthesia, there is no consensus on best drugs or doses to deliver. The purpose of this clinical trial is to clarify the influence of chronic cannabis use during office based general anesthesia for extraction of teeth. The procedures will be performed in the Oral and Maxillofacial Surgery Clinic at the College of Dentistry.
Interventions
Patients will have teeth extracted under sedation with Midazolam, Fentanyl, and Propofol
PROCEDUREExtraction of teeth
The necessary teeth will be extracted
Sponsors
University of Oklahoma
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
DIAGNOSTIC
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Patients older than 18 years of age * Class I or II according to the American Society of Anesthesiology (ASA) * Need for dental extractions * Extraction procedures with similar level of complexity
Exclusion criteria
* Surgical time lesser than 10 or greater than 30 minutes * ASA status of III or greater * BMI greater than 30 k/m2 * Pregnancy * Use of anti-depressants, sedatives, or other mood-altering medications * History of illicit substance abuse, alcoholism, or chronic opioid use
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Propofol dose in milligrams | During the procedure | Compare the total amount of propofol necessary to sedate patients that use cannabis with patients that do not use |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Heart rate in beats per minute | During the procedure | Compare how the heart rate behave during the procedure in each group |
| Blood pressure in millimeters of mercury | During the procedure | Compare how the blood pressure behave during the procedure in each group |
| Quality of sedation grading from 0 to 6 according to the Observer's Assessment of Alertness/Sedation scale | During the procedure | Compare the difference in sedation quality during the procedure in each group |
Countries
United States
Outcome results
None listed