Unrecognized Condition
Conditions
Keywords
Intravascular laser irradiation of blood, He-Ne laser, Poor ovarian responder, Assisted reproductive technology, In vitro fertilization, Anti-aging
Brief summary
The aim of this study was to investigate the effects of intravascular laser irradiation of blood on outcomes of in vitro fertilization cycles in poor ovarian responders.
Detailed description
Intravascular laser irradiation of blood (ILIB) with He-Ne laser (632.8nm) has been applied on many organs and on the hematologic and immunologic system. Quite a number of both animal and human experiments have demonstrated that ILIB has a wide range of effects, including biostimulation, analgesia, antiallergic effects, immunomodulation, vasodilatation, antihypoxic, anti-oxidant, anti-aging and anti-inflammatory effects. Poor ovarian responders (PORs) defined as poor or no response to ovarian stimulation had poor prognosis in assisted artificial technique (ART), which is a great challenge in in vitro fertilization (IVF) cycles. Previous studies showed that treatment with anti-oxidants could improve the outcomes of the poor ovarian responders; however, the effect is limited. Since ILIB has anti-aging, anti-oxidant and anti-inflammatory effects, the investigators hypothesize that ILIB may improve ovarian function and oocyte quality in PORs. Therefore, the investigators attempt to explore the effects of ILIB on the IVF outcomes in women with poor ovarian response.
Interventions
Intravascular laser irradiation of blood via an intravenous catheter for irradiation of the blood under a period of 60 minutes daily for 20 days
Sponsors
Kaohsiung Veterans General Hospital.
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
30 Years to 44 Years
Healthy volunteers
No
Inclusion criteria
* Women who undergoes IVF cycles * BMI:18-30 kg/m2 * Diminished ovarian reserve (AFC\<5, AMH\<1.2 ng/ml)
Exclusion criteria
* Primary ovarian insufficiency * Congenital uterine anomaly * Severe intrauterine adhesion * Severe male factor (azoospermia) * Chromosome anomaly * Malignancy * Donor cycles
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Ongoing pregnancy rate | through study completion, an average of 1 year | continuous presence of a fetal heartbeat over 12 weeks of a pregnancy |
| Ovarian reserve marker | through study completion, an average of 1 year | Anti-mullerian hormone levels |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| mitochondrial function of cumulus cells | through study completion, an average of 1 year | Oxygen consumption and adenosine triphosphate production |
Countries
Taiwan
Outcome results
None listed