Acute Myocardial Infarction
Conditions
Keywords
STEMI, Troponin, Intramyocardial Hemorrhage, Cardiac MRI
Brief summary
Pilot trial to determine diagnostic efficacy of post-reperfusion troponin kinetics in detection of hemorrhagic myocardial infarction
Interventions
None listed
Sponsors
Rohan Dharmakumar
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Age ≥ 18 years 2. Index STEMI 3. Coronary angiogram with PCI to occur irrespective of the onset of the symptoms. 4. Ability to provide informed consent for themselves
Exclusion criteria
1. History of prior myocardial infarction, 2. Cardiogenic shock, 3. Patients who present with current cardiac arrest 4. Any contraindication to cardiac CMR (claustrophobia, pacemaker or cardiac defibrillator, known allergy to gadolinium), 5. Presence of permanent atrial fibrillation, 6. Unconscious patient, 7. Severe renal insufficiency (creatinine clearance ≤ 30 ml/min/m2 or renal replacement therapy), 8. Women who are pregnant or breastfeeding. Women of reproductive potential must have a negative pregnancy test.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Diagnostic Threshold | 48 hours | Levels of markers in hemorrhagic infarct vs. non-hemorrhagic infarct |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Area under the curve (AUC) for serum troponin-I | 48 hours | area under the curve post-MI for troponin-I |
| Hemorrhagic infarct size | 48 hours | as determined by cardiac MRI |
| Peak levels of serum troponin-I | 48 hours | peak levels of serum troponin-I in hemorrhagic infarct vs non-hemorrhagic infarct |
| Hemorrhagic infarct microvascular obstruction | 48 hours | as determined by cardiac MRI |
| Hemorrhagic infarct area at risk | 48 hours | as determined by cardiac MRI |
| Hemorrhagic infarct volume | 48 hours | as determined by cardiac MRI |
Countries
India, United States
Outcome results
None listed