Aging, Arterial Stiffness, Cardiovascular Function, Endothelial Dysfunction
Conditions
Brief summary
The primary goal of this intervention is to determine the efficacy of acute mitochondrial-specific antioxidants to improve vascular endothelial function in middle-aged and older (≥45 y) adults who do no perform regular aerobic exercise. In a double-blind, randomized, placebo-controlled crossover design participants with receive both MitoQ and placebo arm of the study. Primary endpoints will include vascular endothelial function assessed by brachial artery flow-mediated dilation and cardiac function assessed via pulse wave analysis. Secondary endpoints will include measures of aortic stiffness assessed by carotid-femoral pulse wave velocity and carotid artery stiffness (e.g. β-stiffness) and elasticity (carotid compliance, distensibility, and Youngs elastic modulus) from ultrasonography.
Interventions
DIETARY_SUPPLEMENTPlacebo
Gelatin capsules
DIETARY_SUPPLEMENTMitoquinone Mesylate
MitoQ was given once (single dose, 80 mg)
Sponsors
Ball State University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
DOUBLE (Subject, Outcomes Assessor)
Masking description
Double-blind, placebo-controlled
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Resting brachial blood pressure \<160 mmHg (systolic)/\<100 mmHg (diastolic) * Body mass index ≤ 35 kg/m2 * Nonsmoker * Women must be postmenopausal defined as cessation of menses ≥ 1 year.
Exclusion criteria
* cardiovascular/metabolic medications * known clinical disease * absolute contraindications to exercise testing
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in vascular endothelial function | Baseline and Post 1 hour | Brachial artery flow-mediated dilation (% \[relative\] and mm \[absolute\]) |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in carotid artery stiffness - beta-stiffness index | Baseline and Post 1 hour | Carotid artery Beta stiffness index (AU) |
| Change in cardiovascular function | Baseline and Post 1 hour | Subendocardial viability ratio (%) |
| Change in Aortic Stiffness | Baseline and Post 1 hour | Carotid-femoral pulse wave velocity (meters/second) |
| Change in carotid artery distensibility | Baseline and Post 1 hour | Carotid artery distensibility (10\^-3/kilopascals) |
| Change in carotid artery Young's elastic modulus | Baseline and Post 1 hour | Carotid artery Young's elastic modulus (kilopascals, kPa) |
| Change in carotid artery compliance | Baseline and Post 1 hour | Carotid artery compliance (mmHg/mm\^2) |
Countries
United States
Outcome results
None listed