Malignant Pleural Effusion, Thoracic Cancer
Conditions
Keywords
Malignant pleural effusion, VATS, PleurX, Abrasion
Brief summary
Malignant Pleural Effusion (MPE) is considered to be a common presentation at malignant tumors representing 15% of all cancer cases. It carries a burden on our patients with dyspnea being the most common symptom in most of cases. Management of symptomatic malignant pleural effusion remains to be a point of debate. Data available from literature shows conflicting results lacking high quality evidence which necsscitates further research work. Options differs to include chemical pleurodesis using medical or surgical talc poudrage or slurry. Surgical intervention with abrasion pleurodesis or pleurectomy using VATS approach has been used in many studies. Using indwelling pleural catheters (IPCs) has also proved comparable efficacy at many clinical trials. In this study we want to help answering this question so that we can add to the current knowledge aiming to offer the best care for those patients
Interventions
PROCEDUREVATS-Surgical pleurodesis
VATS drainage and surgical abrasion.
PROCEDURETube Drainage
Tube drainage for malignant pleural effusion
Sponsors
Assiut University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Intervention model description
Randomised Clinical Trial with 2 groups; Case group for VATS mechanical abrasion and Control group for tube drainage
Eligibility
Sex/Gender
ALL
Age
5 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
* 1-patients with symptomatic malignant pleural effusion. 2- symptomatic patients with shortness of breath. 3-Lung can be fully expanded.
Exclusion criteria
1. Patients with non symptomatic malignant pleural effusion 2. Pleural symphysis with no potentiality for re-expansion 3. Patients managed surgically through open thoracotomy. 4. Pleural effusion due to causes other than malignancy 5. Loculated malignant effusion judged by chest ultrasound 6. Trapped lung due to malignant pleural effusion assessed by multislice CT chest., 7. .Refusal to share the research project and not to sign the consent.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Total hospital stay | 3 months postoperative | duration of hospital stay in days |
| duration of airleak | 3 months postoperative | duration in days |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Status of performance | 3 months | patient reported outcome through a pre-prepared questionnaire |
| mortality | '3 months | Rate of mortality |
| Failure of management | 3 months | time to re-collection |
Countries
Egypt
Contacts
Primary ContactKareem A Hosny, M.SC
Outcome results
None listed