Fertility Issues
Conditions
Brief summary
The present study is aimed to explore the treatment effect from the intake of probiotic Lactobacillus crispatus M247 in the improvement of clinical and psychological aspects in women undergoing homologous level 2 ART procedures.
Detailed description
The use of assisted reproductive technology (ART) has increased dramatically worldwide due to the continuous rise in infertility rates; for these reasons an increasing number of couples undertake the path of ART, even though this is difficult journey, with uncertain outcomes and possible medical risks, both physical and psychological. In this study the investigators aim to explore the hypothesis that recreating a favorable vaginotype through the intake of the probiotic Lactobacillus crispatus M247 can have a positive effect in achieving pregnancy in cryopreserved cycles as well as a positive relationship between vaginal, endometrial (still unknown), gut and oral microbiota.
Interventions
DIETARY_SUPPLEMENTProbiotic Lactobacillus crispatus M247
Patient who have received probiotic Lactobacillus crispatus M247
Sponsors
Treviso Regional Hospital
Dr. Amjad Khan
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Eligibility
Sex/Gender
FEMALE
Age
18 Years to 45 Years
Healthy volunteers
No
Inclusion criteria
* Women undergoing homologous level 2 assisted reproductive technology (ART) procedures * Cryopreserved oocytes * D3 embryos * D5 blastulae * Age 18-45
Exclusion criteria
* Presence of submucous uterine myomas. * Uterine malformations.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Pregnancy | up to 12 months | Rate of pregnancy |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Effect on sex hormonal profile | up to 12 months | change in anti-mullerian hormone levels |
Countries
Italy
Outcome results
None listed