Acute Kidney Injury
Conditions
Keywords
Acute kidney injury, Cardiopulmonary bypass, gene expression
Brief summary
The goal of this observational study is to learn about the changes in gene expression in blood immune cells in after cardiac surgery with cardiopulmonary bypass.The main question it aims to answer is: What specific gene expression changes predict kidney damage after cardiac surgery with cardiopulmonary bypass. Participants received conventional treatment.
Interventions
OTHERGene sequencing
Participants were taken blood samples for gene sequencing at three time periods: before, after, and 24 hours after the end of the surgery
Sponsors
Second Affiliated Hospital, School of Medicine, Zhejiang University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* 1\) Age≥ 18 years old; 2) Cardiopulmonary bypass descending valve replacement (molding), or coronary artery bypass grafting, or macrovascular surgery.
Exclusion criteria
* 1\) any cognitive or mental impairment that is unable to sign the informed consent form; 2) Have basic immune system and blood system diseases; 3) pregnancy; 4) Receiving radiotherapy and chemotherapy before surgery; 5) Receiving immunosuppressive drugs within six months; 6) Have participated in other interventional clinical trials within 30 days before surgery. Exit Criteria: 1. Incomplete surgery; 2. Secondary transfer in the operating room; 3. Automatically request to terminate the test.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Postoperative acute kidney injury | Within 48 hours after surgery | SCr was elevated ≥ 26.5 micromol/L or 1.5 times the baseline for SCr ≥ or urine output \< 0.5 mL/kg/hour within 6 hours within 48 hours |
Countries
China
Outcome results
None listed