Sarcopenia
Conditions
Keywords
muscle mass, strength, omega-3, ageing
Brief summary
The aim of the study is to compare the effects of Krill Oil and Fish Oil supplementation on muscle function in older adults. The secondary aim is to investigate the mechanisms underlying the beneficial effects previously observed.
Interventions
DIETARY_SUPPLEMENTFish oil
EPA rich fish oil
DIETARY_SUPPLEMENTKril oil
Superba Krill Oil
DIETARY_SUPPLEMENTVegetable oil
Mixed vegetable oil
Sponsors
University of Glasgow
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Masking description
Supplements will be identical in look and taste
Intervention model description
1:1:1 basis
Eligibility
Sex/Gender
ALL
Age
60 Years to 90 Years
Healthy volunteers
Yes
Inclusion criteria
* Older adults (aged 60 years or older). BMI less than 30kg/m2
Exclusion criteria
* Participants (diagnosed and being treated for a pre-existing medical condition (cancer, kidney disease, liver disease, diabetes mellitus and cardiovascular disease, uncontrolled hypertension, gait disturbances limiting the ability to perform assessments of muscle function, dementia, affecting muscles known to use drugs (e.g., steroids). History of allergy to fish or fish oil and regular consumption of more than1portion of oily fish per week or use of fish oil or krill oil supplements will also be excluded.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in knee extensor maximal isometric torque ( MVC) | Change from baseline to 16 weeks | Knee extensor maximal isometric torque measured during a maximal voluntary contraction |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in lean mass | Change from baseline to 16 weeks | Whole body lean mass measured by measured via bio-electrical impedance |
| Blood sample | Change from baseline to 16 weeks | Red Blood Cell Omega-3 levels |
| Change in Grip strength | Change from baseline to 16 weeks | Grip strength measured with a hand held dynamometer |
| Change in Muscle thickness | Change from baseline to 16 weeks | Vastus lateralis muscle thickness measured by ultrasound |
| Change in fat mass | Change from baseline to 16 weeks | Whole body fat mass measured by measured via bio-electrical impedance |
| Neuromuscular Junction (NMJ) | Change from baseline to 16 weeks | Measured by iEMG |
| Change in gait speed | Change from baseline to 16 weeks | Time taken to walk 4 metres at a normal walking pace |
| Change in Chair rise time | Change from baseline to 16 weeks | A 30-second sit-to-stand test measured functional abilities |
| Force steadiness during submaximal isometric knee extensor contractions | Change from baseline to 16 weeks | Measured by using intramuscular iEMG |
Other
| Measure | Time frame | Description |
|---|---|---|
| Toe In/ Out (deg) | Change from baseline to 16 weeks | Measured during a 4m walk using a gaitrite mat |
| Distance (CM) | Change from baseline to 16 weeks | Measured during a 4m walk using a gaitrite mat |
| Ambulation Time (Sec) | Change from baseline to 16 weeks | Measured during a 4m walk using a gaitrite mat |
| Velocity (CM/Sec) | Change from baseline to 16 weeks | Measured during a 4m walk using a gaitrite mat |
| Mean Normalized Velocity | Change from baseline to 16 weeks | Measured during a 4m walk using a gaitrite mat |
| Double Support (%GC) | Change from baseline to 16 weeks | Measured during a 4m walk using a gaitrite mat |
| Cadence (Steps/Min) | Change from baseline to 16 weeks | Measured during a 4m walk using a gaitrite mat |
| Step Time Differential (Sec) | Change from baseline to 16 weeks | Measured during a 4m walk using a gaitrite mat |
| Step Length Differential (CM) | Change from baseline to 16 weeks | Measured during a 4m walk using a gaitrite mat |
| Cycle Time Differential (Sec) | Change from baseline to 16 weeks | Measured during a 4m walk using a gaitrite mat |
| Number of Steps | Change from baseline to 16 weeks | Measured during a 4m walk using a gaitrite mat |
| Swing (%GC) | Change from baseline to 16 weeks | Measured during a 4m walk using a gaitrite mat |
| Stance (%GC) | Change from baseline to 16 weeks | Measured during a 4m walk using a gaitrite mat |
| Step/ Extremity Ratio | Change from baseline to 16 weeks | Measured during a 4m walk using a gaitrite mat |
| Step Time (Sec) | Change from baseline to 16 weeks | Measured during a 4m walk using a gaitrite mat |
| Cycle Time (Sec) | Change from baseline to 16 weeks | Measured during a 4m walk using a gaitrite mat |
| Step Length (CM) | Change from baseline to 16 weeks | Measured during a 4m walk using a gaitrite mat |
| Stride Length (CM) | Change from baseline to 16 weeks | Measured during a 4m walk using a gaitrite mat |
| H-H Base Support (CM) | Change from baseline to 16 weeks | Measured during a 4m walk using a gaitrite mat |
| Single Support (%GC) | Change from baseline to 16 weeks | Measured during a 4m walk using a gaitrite mat |
Countries
United Kingdom
Outcome results
None listed