Autoantibodies, Interleukin-6
Conditions
Brief summary
The aim of the project is to investigate whether or not there are any difference in cardiometabolic outcomes in individuals with high or low levels of c-aAb against interleukin-6 (IL-6). The study is the first to investigate individuals with extreme amounts of c-aAb levels against IL-6 and to contribute with knowledge on a possible new phenotype.
Interventions
OTHEROral Glucose Tolerance Test
75g oral glucose tolerance test, sampled over three hours
OTHERCycling test
2 hours of moderate activity level cycling
Sponsors
Clinical Immunological Department, Rigshospitalet
The Danish Blood Donor Study
University of Copenhagen
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Intervention model description
Groups defined by autoantibodies status (high or low)
Eligibility
Sex/Gender
ALL
Healthy volunteers
Yes
Inclusion criteria
* Fulfill Danish blood donor criteria * Have extreme amounts of IL-6 c-aAb or matched as control (low amounts of IL-6 c-aAb)
Exclusion criteria
* Failure to fulfill Danish blood donor criteria
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Inflammatory markers | Measurements over a three-hour oral glucose tolerance test, a two-hour cycling test, and one hour of recovery | IL-6 plasma levels, plasma IL-6 c-aAb levels |
| Whole-body glucose metabolism | Measurements over a three-hour oral glucose tolerance test, a two-hour cycling test, and one hour of recovery | Plasma levels of: Insulin |
| Cardiovascular risk markers | Measurements over a three-hour oral glucose tolerance test, a two-hour cycling test, and one hour of recovery | Lipids |
| Difference in exercise response | Measurements over a two-hour cycling test, and one hour of recovery | 2-hour Lactate |
| Metabolic response during exercise | Measurements over a three-hour oral glucose tolerance test, a two-hour cycling test, and one hour of recovery | 2-hour glucose |
| Metabolic assessment of the liver | An MRI-scanning withinn four weeks of the oral glucose tolerance test | Liver fat content from MRI-scanning, and HOMA-IR |
Countries
Denmark
Contacts
Primary ContactTorben Hansen, PhD
Backup ContactRasmus T Jensen, MSc
Outcome results
None listed