Gastrointestinal Dysfunction, Postoperative Complications, Surgery
Conditions
Keywords
gastrointestinal dysfunction, high risk surgery, postoperative
Brief summary
This study aims to find out the role of plasma I-FABP level, SOFA score, fluid balance, and vasopressor dose in predicting gastrointestinal dysfunction in high-risk postoperative patients treated in ICU
Detailed description
This is a prospective cohort study to find out the role of plasma I-FABP level, SOFA score, fluid balance, and vasopressor dose in predicting gastrointestinal dysfunction in high-risk postoperative patients treated in ICU. The characteristics of patients who meet the eligibility criteria were obtained. Blood sampling during admission is done for I-FABP level measurement and will be repeated after 24 hours. Blood sample which is not directly processed will be stored in refrigerator under 6-8C temperature. Evaluation of Acute Gastrointestinal Injury signs and symptoms is done. The re-evaluation is performed every day. If patients experiencing AGI signs and symptoms, monitoring and treatment based on condition are done. Routine follow-up is continued during hospitalisation in ICU. After all sample are collected, I-FABP level is assessed quantitatively using ELISA.
Interventions
None listed
Sponsors
Aldy Heriwardito
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* High-risk postoperative patients * Patients treated in Intensive Care Unit of Emergency Department or Surgery Unit in Cipto Mangunkusumo General Hospital * Age \>18 years old * Patients or family give written consent to follow the study
Exclusion criteria
* Patients with late trimester-pregnancy when admitted to ICU * Patients undergo cardiac surgery * Patients with gastrointestinal disorders requiring routine therapy * Patients undergo surgery involving bowels * Patients undergo surgical treatment for burn * Patients treated in ICU \>24 hours before surgery Drop-out Criteria * Unable to obtain blood sampling for I-FABP level examination in ICU * Unable to perform Acute Gastrointestinal Injury examination in ICU * Patients died within \<24 hours treatment in ICU * Patients or family decide to quit from the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| I-FABP plasma level | During admission | I-FABP plasma level is measured during admission and 24 hours after. I-FABP plasma level during admission is used as the data, while the 24 hours after admission is used to evaluate any bowel injury during treatment in ICU. |
| Vasopressor dose | During surgery (intraoperative period) | Mean dose of norepinephrine (mcg/kg/min) used during intraoperative period. It is measured proportionally to the duration of use based on anesthesia record. |
| SOFA score | During admission in ICU (postoperative period) | Score used to evaluate patients' status during treatment in ICU and to determine the severity of organ dysfunction. It is measured during patients' admission to ICU |
| Fluid balance | During surgery (intraoperative period) | The net between fluid output and input during intraoperative period. |
Countries
Indonesia
Contacts
Primary ContactAldy Heriwardito, MD
Outcome results
None listed