Platelet-rich Fibrin
Conditions
Brief summary
A Randomized, controlled clinical trial and split-mouth design was performed to assess and compare the effect of platelet-rich fibrin (PRF) on soft tissue healing, periodontal pocket depth and alveolar bone height distal to second molar of the study and control groups after third molar surgical removal. Sample include of participants who had indication of impacted lower third molars extraction on both sides with symmetrically orientation and same difficult index. All participants had same extraction protocol on both side at Department of Oral surgery, Faculty of Odonto-stomatology, University of Medicine and Pharmacy, Ho Chi Minh City. Soft tissue healing, periodontal pocket depth and distal bone height were evaluation by an independent investigator.
Interventions
OTHERPRF
centrifuge patient's blood to collect 1 block of yellowish condensed fibrin, which is platelet-rich fibrin
OTHERstandard third molar surgical removal
standard third molar surgery following surgical protocol of Department of Oral Surgery, University of Medicine and Pharmacy
Sponsors
Lam Cu Phong
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
SUPPORTIVE_CARE
Masking
DOUBLE (Investigator, Outcomes Assessor)
Intervention model description
split-mouth study, 1 side would be the study side and other side would be control side
Eligibility
Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
Yes
Inclusion criteria
* Patient over 18 years old. * Good general health. * Bilateral lower third molars equivalent in inclination and Pell and Gregory's impaction classification (classification II, III and B, C). The assessment of equivalence between two mandibular third molars was determined on the panoramic radiograph. * The difference of third molar inclination on both sides not greater than 15 degrees. * The patient consented to participate in the study after hearing clearly the explanation of purposes and requirements of the study.
Exclusion criteria
* Patients with any systemic disease contraindicated for surgery. * Presence of acute inflammation or infection at third molar areas. * Patients refused to participate in the study, did not comply with treatment or did not come to the follow-up examination as required. * The difference in surgical time between the two groups was more than 10 minutes.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| distal bone resorption | 3rd postoperative month | resorption of alveolar bone height distal to second molar |
| periodontal pocket depth | 1rst postoperative month | periodontal pocket depth at distal buccal and distal lingual side of second molar |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| soft tissue healing index | 3rd postoperative day | soft tissue healing around third molar socket |
Countries
Vietnam
Outcome results
None listed