Neurocognitive Disorders
Conditions
Brief summary
This study aims to compare the effect of a program of Adapted Physical Activity (APA) versus the same program combined with a physical activity education program (PAE). Patients suffering from neurocognitive disorders (mild or early major) will be randomized into one of the two conditions. 3 complete evaluations will be done (inclusion M0, after 3 month of intervention M3, 3 months after the end of the intervention M6). The team except that APA+PEA will be more effectiv than the APA solely, on the following criteria : level of physical activity, cogntive function and quality of life.
Sponsors
Centre Hospitalier Universitaire de Nice
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
70 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* mild neurocognitive disorder or early major neurocognitive disorder
Exclusion criteria
* Medical pathology involving the vital prognosis in the short term * Major neurocognitive disorder at moderate stage and beyond (DSM 5) and/or MMSE \< 20 * Unbalanced depressive syndrom * Contraindication to the practice of the exercises proposed during the study; * Major hearing or visual impairment; * Sufficiently active with regard to the daily recommendations described by the WHO
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| physical activity level | at inclusion | evolution of physical activity level will be assessed by actimetry on a 7 days period mesured by IPAQ score |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| global cognition | at inclusion | global cognition will be assessed by a MMSE test (Mini Mental State Examination) mesured by a score |
| executive functions | at inclusion | executiv functions will be assessed by FAB (frontal assessment battery) |
| executive functions (FAB) | at inclusion | executiv functions will be assessed by FAB (frontal assessment battery) giving a score |
| executive functions (TMT) | at inclusion | executiv functions will be assessed by TMT (frontal assessment battery) - giving a score |
| cardiovascular performance | at inclusion | Cardiovascular performance will be evaluated through a effort test that will be performed on a stationary bicycle ergometer connected to a portable gas exchange analysis system in ml/kg/min |
| power - physical condition | at inclusion | physical condition will be asessed by lower extremity power (isokinetic ergometer) with a score |
| strenght - physical condition | at inclusion | physical condition will be asessed by grip strength (hand grip) with a score |
| evaluation of quality of life | at inclusion | quality of life will be assessed by SF 12 a short version of the MEDICAL OUTCOME STUDY SHORT FORME GENERAL HEALTH SURVEY (score) |
| anxiety and depression | at inclusion | anxiety and depression will be assessed by the HADS " Hospital Anxiety and Depression Scale " and giving a score |
| apathy | at inclusion | apathy will be assessed by the apathy inventory questionnary and givig a score |
Countries
France
Contacts
CONTACTJustine Lemaire
Outcome results
None listed