COVID-19 Acute Respiratory Distress Syndrome
Conditions
Brief summary
The primary objective of this study is to evaluate the effects of a 15-week home telerehabilitation program and a detraining period on cardiorespiratory fitness and muscular efficiency in patients with post-COVID-19 sequelae compared to a control group of COVID-19 patients. We hypothesize that cardiorespiratory fitness and muscular efficiency significantly improve in patients who carry out the home telerehabilitation program. However, the cardiorespiratory and muscular adaptations achieved and tolerance to exercise are lost over time as an effect of detraining.
Interventions
The supervised telerehabilitation program will be performed in the home of each patient and supervised by an experienced physiotherapist with more than 4 years of clinical experience in therapeutic exercise for chronic diseases.
Sponsors
Campus docent Sant Joan de Déu-Universitat de Barcelona
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* age \> 18 years * molecular diagnosis (reverse transcription polymerase chain reaction \[RT-PCR\]) of infection by SARS-CoV-2 * post-COVID-19 symptomatology
Exclusion criteria
* severe neurological disease * active oncological disease * neuromuscular disease and/or orthopedic disorders impeding normal development of cardiopulmonary exercise test * the absence of signed informed consent
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cardiorespiratory fitness: absolute oxygen uptake | 1 week per group | absolute peak oxygen uptake in L/min |
| Cardiorespiratory fitness: relative oxygen uptake | 1 week per group | relative peak oxygen uptake in L/min |
| Exercise capacity during cardiopulmonary exercise test | 1 week per group | Exercise time in minutes and seconds |
| Mechanical efficiency | 1 week per group | Delta efficiency in percentage |
| Ventilatory efficiency | 1 week per group | VE/VCO2 slope |
| Power output during pedaling | 1 week per group | Power output in watts |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Respiratory exchange ratio | 1 week per group | RER |
| ventilatory equivalent for carbon dioxide | 1 week per group | VE/VCO2 |
| ventilatory equivalent for oxygen | 1 week per group | VE/VO2 |
| Minute ventilation | 1 week per group | Ventilation in L/min |
| End-tidal partial pressure of oxygen | 1 week per group | PetO2 in mmHg |
| end-tidal partial pressure of carbon dioxide | 1 week per group | PetCO2 in mmHg |
| Weight of COVID-19 patients | 1 week per group | Weight in kg |
| Height of COVID-19 patients | 1 week per group | Height in meters |
| Body mass index of COVID-19 patients | 1 week per group | BMI in kg/m2 |
Countries
Spain
Outcome results
None listed