Cancer Survivors, Leukemia, Lymphoma, Musculoskeletal Complication
Conditions
Brief summary
Haematological cancer treatment often includes use of high dose glucocorticoids (steroids), chemotherapy and radiotherapy and current evidence suggests that these patients may have lower bone mineral density after treatment when compared to the general population which can predispose them to increased risk of fragility fractures. Evidence of the impact of these musculoskeletal burden to patients (e.g. quality of life) are not available. This study aims to describe musculoskeletal complications experienced by long-term haematological cancer survivors and examine the impact of the burden from the patient perspective. The study will be conducted in 2 parts; a questionnaire study and an interview study to help understand the extent of musculoskeletal problems experienced by this group of patients and the impact of this on quality of life.
Interventions
This is a study administering questionnaire and interviews using mixed quantitative and qualitative methodology with the aim to describe and evaluate musculoskeletal health of adult haematological cancer survivors and its impact to survivors.
Sponsors
National Institute for Health Research, United Kingdom
The Christie NHS Foundation Trust
Study design
Observational model
OTHER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
Questionnaire study Inclusion Criteria: 1. Age 18 or above at diagnosis of haematological cancer 2. Diagnosis of haematological cancers: lymphoma or leukaemia 3. Cancer survivors as recorded in the local database of lymphoma and haematopoietic stem cell transplant database 4. Able to give written informed consent 5. Able to read and understand English
Exclusion criteria
1.Currently receiving any active cancer treatment Interview study Inclusion Criteria: 1. Age 18 or above at diagnosis of haematological cancer 2. Diagnosis of haematological cancers: lymphoma or leukaemia 3. Cancer survivors as recorded in the local database of lymphoma and haematopoietic stem cell transplant database 4. Able to give written or verbal informed consent 5. Able to read and understand English
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Questionniare study: To measure prevalence of musculoskeletal conditions and related symptoms experienced by adult lymphoma and leukaemia survivors | overall length of the study - 6 months | Musculoskeletal conditions and related symptoms will be recorded by patients on the study specific questionnaire and the validated questionnaire Nordic musculoskeletal questionnaire (NMQ-E) and gait, arms, legs and spine (GALS) assessment |
| Questionniare study: To calculate the 10-year probability of hip fracture and major osteoporotic fracture (clinical spine, forearm, hip or shoulder fracture) of adult lymphoma and leukaemia survivors | overall length of the study - 6 months | The 10-year probability of hip fracture and major osteoporotic fracture (clinical spine, forearm, hip or shoulder fracture) of adult lymphoma and leukaemia survivors will be calculated using the Fracture Risk Assessment Tool (FRAX) and Q-Fracture calculator. |
| Questionniare study: To measure prevalence of sarcopenia and frailty among adult lymphoma and leukaemia survivors | overall length of the study - 6 months | Validated questionniares will be used to assess if patients have sarcopenia (SARC-F questionnaire) and frailty (FiND questionnaire). |
| Questionniare study: To assess quality of life and musculoskeletal function related quality of life of adult lymphoma and leukaemia survivors | overall length of the study - 6 months | This will be assessed using validated questionnaires - Short Form Survey (SF36) and Short Musculoskeletal Function Assessment (SMFA). |
| Interivew study: To describe experience of adult lymphoma and leukaemia survivors on musculoskeletal health, musculoskeletal related care and musculoskeletal health information provision. | overall length of the study - 6 months | Semi-structured qualitative interviews will be conducted with a topic guide to ensure same broad topics are explored in the interviews on musculoskeletal health experience, care and information provision. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Questionnaire study: To describe the likely risk factors that may be associated with musculoskeletal consequences of adult lymphoma and leukaemia survivors Impact of musculoskeletal health | overall length of the study - 6 months | This will be assessed using regression analysis to determine risk factors that may be associated with poor musculoskeletal health |
Countries
United Kingdom
Contacts
Primary ContactSalina Tsui, MSc
Backup ContactClaire Higham, PhD
Outcome results
None listed