Sedentary; Aging
Conditions
Brief summary
This project will determine the independent and combined effects of aerobic exercise and time restricted fasting on cardiovascular risks among sedentary middle-aged and elderly adults. The online intervention period will be eight weeks. Before and after the intervention, arterial stiffness, cardiac autonomic nervous, body composition, glucolipid metabolism, sleep and eating habits, inflammatory reaction, sedentary behavior and physical activity level will be measured and compared between groups who are doing either aerobic exercise, time restricted fasting, both aerobic exercise and time restricted fasting, or who are in a control group. Adverse reaction, sleep and eating quality, life quality and adherence to the interventions and hunger/satiety will also be measured.
Interventions
BEHAVIORALAerobic Exercise
Three weekly, supervised exercise sessions with aerobic exercise. Each session will last for 60-65 minutes, each period will be consist of 5 min warm up, 45 min formal training and 5-10 min relaxation training. Intervention period will be eight weeks.
BEHAVIORALTime Restricted Fasting
Restricted daily window of caloric intake to maximum 8 hours. Intervention period will be eight weeks.
Sponsors
Guangdong Provincial Key Laboratory of Physical Activity and Health Promotion
Guangdong Provincial Scientific Research Center
Guangzhou Sport University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
45 Years to 69 Years
Healthy volunteers
Yes
Inclusion criteria
* Age: 45-69 years old Sedentary time ≥8 hours per day * Irregular exercise habits * No drugs affecting the outcome index were taken * No history of serious diseases * Sign the subject informed consent and agree to participate in this experiment.
Exclusion criteria
* The range of body weight change in the last three months is more than 3kg * People taking weight-loss drugs * Participate in other experimenters 5 months before the experiment * Unable to adjust and follow the intervention schedule.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change of cardiovascular risk estimated by heart rate variability | From baseline to after 8 weeks intervention | — |
| Change of cardiovascular risk estimated by ankle-brachial index | From baseline to after 8 weeks intervention | — |
| Change of cardiovascular risk estimated by pulse wave velocity | From baseline to after 8 weeks intervention | — |
| Change of cardiovascular risk estimated by flow-mediated transition | From baseline to after 8 weeks intervention | — |
| Change of cardiovascular risk estimated by cytokines level | From baseline to after 8 weeks intervention | Fasting matrix metalloproteinases, norepinephrine, and neuropeptide Y cytokines level in blood |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Diet habits | From baseline to after 8 weeks intervention | Self-reported: diet habits were assessed using the Adult Eating Behavior Questionnaire (AEBQ). With higher scores indicating worse eating habits (represented by emotional over-eating and emotional under-eating) or better dietary (represented by food responsiveness, enjoyment of food, satiety responsiveness, food fussiness and slowness in eating). |
| Sleep quality | From baseline to after 8 weeks intervention | Self-reported: sleep quality was indicated by the Pittsburgh Sleep Quality Index (PSQI) Questionnaire. The maximum score of the sleep quality index is 21 points,scores higher than 5 indicate poor sleep quality, with higher scores indicating poorer sleep quality. |
| Life quality | From baseline to after 8 weeks intervention | Self-reported: life quality was indicated by The World Health Organization Quality of Life (WHOQOL)-BREF Questionnaire. With higher scores indicating better life quality. |
| Physical activity | From baseline to after 8 weeks intervention | Physical activity were measured by using accelerometer (ActiGraph GT3X+ model, USA).Measured by using accelerometer (ActiGraph GT3X+ model, USA). Accelerometer was used for 7 consecutive days, being affixed to the nondominant wrist. |
| Sedentary activity | From baseline to after 8 weeks intervention | Sedentary activity were measured by using accelerometer (ActiGraph GT3X+ model, USA).Measured by using accelerometer (ActiGraph GT3X+ model, USA). Accelerometer was used for 7 consecutive days, being affixed to the nondominant wrist. |
| Inflammation level | From baseline to after 8 weeks intervention | Inflammation level were measured by Enzyme-linked immuno sorbent. |
| Weight | From baseline to after 8 weeks intervention | In kg |
| High density lipoprotein in blood | From baseline to after 8 weeks intervention | Fasting high density lipoprotein in blood |
| Low density lipoprotein in blood | From baseline to after 8 weeks intervention | Fasting low density lipoprotein in blood |
| Triglycerides in blood | From baseline to after 8 weeks intervention | Fasting triglycerides in blood |
| Diet in take | From baseline to after 8 weeks intervention | Self-reported: Mint Health application. |
| Adherence to intervention | From baseline to after 8 weeks intervention | Self-reported: WeChat application, number of completed exercise sessions out of those prescribed, in percentage. |
| Adverse reaction | From baseline to after 8 weeks intervention | Self-reported: mini program. |
| Cholesterol in blood | From baseline to after 8 weeks intervention | Total fasting cholesterol in blood |
| body fat | From baseline to after 8 weeks intervention | In kg |
| Lean body mass | From baseline to after 8 weeks intervention | In kg |
| Body mass Index | From baseline to after 8 weeks intervention | In kg/m\^2 |
| Body fat percentage | From baseline to after 8 weeks intervention | In percent of total body mass |
Countries
China
Outcome results
None listed