Non Small Cell Lung Cancer Metastatic
Conditions
Keywords
brain metastasis, screening
Brief summary
Patients with newly diagnosed stage IV non-oncogene addicted NSCLC, who are fit for systemic treatment and don't have any symptoms of brain disease will undergo an MRI of the brain to screen for brain disease.
Interventions
DIAGNOSTIC_TESTMRI
MRI scan of the brain
Sponsors
University Medical Center Groningen
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SCREENING
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Histologically or cytologically confirmed stage IV metastatic NSCLC, not amenable to curative treatment. * Fit for systemic treatment (PS 0-2) according to standard of care. * No symptoms of brain disease disease assessed according to standard clinical care by the thoracic oncologist.
Exclusion criteria
* Prior/concomitant therapy for stage IV disease. * Oncogenic diver mutation (e.g. EGFR, ALK, ROS1, RET, MET, and BRAF) with approved targeted treatment. * Contraindications for MRI scan with contrast as per standard of care protocol of the institution.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Clinical value of the MRI | up to 6 months after the MRI | Clinical value of the MRI evaluated by the treating thoracic oncologist and assessed by questionnaires completed on three timepoints. |
Countries
Netherlands
Contacts
CONTACTF. Bensch, MD, PhD
CONTACTL.B.M. Hijmering, MD
Outcome results
None listed