E-cigarette Use, Nicotine, Nicotine Vaping
Conditions
Brief summary
The Sweet Spot Study aims to evaluate the effect of e-liquids with nicotine varying in freebase (FB) levels and concentrations on the appeal of electronic cigarettes (ECs) in young adult EC users with minimal/no history of smoking and older adult smokers.
Interventions
BEHAVIORALVaping study EC A
Vaping two puffs using the study EC device
BEHAVIORALVaping study EC B
Vaping two puffs using the study EC device
BEHAVIORALVaping study EC C
Vaping two puffs using the study EC device
BEHAVIORALVaping study EC D
Vaping two puffs using the study EC device
BEHAVIORALVaping study EC E
Vaping two puffs using the study EC device
BEHAVIORALVaping study EC F
Vaping two puffs using the study EC device
BEHAVIORALVaping study EC G
Vaping two puffs using the study EC device
BEHAVIORALVaping study EC H
Vaping two puffs using the study EC device
BEHAVIORALVaping study EC I
Vaping two puffs using the study EC device
BEHAVIORALVaping study EC J
Vaping two puffs using the study EC device
Sponsors
Ohio State University Comprehensive Cancer Center
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
PREVENTION
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
21 Years to 50 Years
Healthy volunteers
Yes
Inclusion criteria
1. Young adult e-cigarette user or older adult smoker 2. Willing to abstain from all nicotine product use for 12 hours prior to the study visit 3. Read and speak English
Exclusion criteria
1. Currently attempting to quit nicotine products 2. Currently pregnant, planning to become pregnant, or breastfeeding 3. Current or past use of tobacco products other than e-cigarettes or cigarettes 4. Self-reported diagnosis of lung disease 5. Self-reported new or unstable cardiovascular disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Behavioral Intentions for Continued Use | The outcome measure was assessed immediately after each vaping session. During each vaping session, participants took two puffs of each of the 10 study conditions within a single study visit lasting up to 3 hours. | Self-report measure on a 7-point scale completed following e-cigarette self-administration. Ratings range from1 (extremely unlikely) to 7 (extremely likely) with higher scores indicating a higher likelihood of continuing to use the product. |
| Intensity of Sensory Attributes | The outcome measure was assessed immediately after each vaping session. During each vaping session, participants took two puffs of each of the 10 study conditions within a single study visit lasting up to 3 hours. | 5-item self-report measure completed following e-cigarette self-administration, using the general Labeled Magnitude Scale (gLMS). Scores range from 0 (no sensation) to 100 (strongest imaginable) with higher scores indicating a greater sensation intensity. |
| Degree of Liking or Disliking of Sensations | The outcome measure was assessed immediately after each vaping session. During each vaping session, participants took two puffs of each of the 10 study conditions within a single study visit lasting up to 3 hours. | Self-report measure completed following e-cigarette self-administration, using the Labeled Hedonic Scale (LHS). Scores range from -100 (most disliked imaginable) to 100 (most liked imaginable) with higher scores indicating a greater degree of liking. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Subjective Appeal | The outcome measure was assessed immediately after each vaping session. During each vaping session, participants took two puffs of each of the 10 study conditions within a single study visit lasting up to 3 hours. | 12-item modified Cigarette Evaluation Questionnaire (mCEQ) completed following e-cigarette self-administration to assess subjective responses to the e-cigarettes. The 12-item mCEQ includes five subscales: Smoking Satisfaction, Psychological Reward, Aversion, Enjoyment of Respiratory Tract Sensations, and Craving Reduction, with items rated from 1 (not at all) to 7 (extremely likely). Scores for each subscale are calculated as the mean of the individual item responses or the single item. Higher scores indicate greater intensity on that scale. |
Countries
United States
Participant flow
Participants by arm
| Arm | Count |
|---|---|
| Young Adult EC Users Young adult e-cigarette users | 66 |
| Older Adult Smokers Older adult cigarette smokers | 67 |
| Total | 133 |
Withdrawals & dropouts
| Period | Reason | FG000 | FG001 |
|---|---|---|---|
| Overall Study | Ineligible | 4 | 12 |
| Overall Study | Pregnancy | 0 | 1 |
| Overall Study | Withdrawal by Subject | 0 | 1 |
Baseline characteristics
| Characteristic | Young Adult EC Users | Older Adult Smokers | Total |
|---|---|---|---|
| Age, Continuous | 22.12 years STANDARD_DEVIATION 1.16 | 39.39 years STANDARD_DEVIATION 6.71 | 30.82 years STANDARD_DEVIATION 9.91 |
| Cigarettes Smoked per Day | 0.02 cigarettes per day STANDARD_DEVIATION 0.12 | 13.19 cigarettes per day STANDARD_DEVIATION 6.33 | 6.65 cigarettes per day STANDARD_DEVIATION 7.99 |
| Race (NIH/OMB) American Indian or Alaska Native | 0 Participants | 0 Participants | 0 Participants |
| Race (NIH/OMB) Asian | 3 Participants | 1 Participants | 4 Participants |
| Race (NIH/OMB) Black or African American | 3 Participants | 9 Participants | 12 Participants |
| Race (NIH/OMB) More than one race | 4 Participants | 3 Participants | 7 Participants |
| Race (NIH/OMB) Native Hawaiian or Other Pacific Islander | 0 Participants | 0 Participants | 0 Participants |
| Race (NIH/OMB) Unknown or Not Reported | 1 Participants | 0 Participants | 1 Participants |
| Race (NIH/OMB) White | 55 Participants | 54 Participants | 109 Participants |
| Sex: Female, Male Female | 51 Participants | 53 Participants | 104 Participants |
| Sex: Female, Male Male | 15 Participants | 14 Participants | 29 Participants |
Adverse events
| Event type | EG000 affected / at risk | EG001 affected / at risk |
|---|---|---|
| deaths Total, all-cause mortality | 0 / 70 | 0 / 80 |
| other Total, other adverse events | 0 / 70 | 0 / 80 |
| serious Total, serious adverse events | 0 / 70 | 0 / 80 |
Outcome results
Primary
Behavioral Intentions for Continued Use
Self-report measure on a 7-point scale completed following e-cigarette self-administration. Ratings range from1 (extremely unlikely) to 7 (extremely likely) with higher scores indicating a higher likelihood of continuing to use the product.
Time frame: The outcome measure was assessed immediately after each vaping session. During each vaping session, participants took two puffs of each of the 10 study conditions within a single study visit lasting up to 3 hours.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Young Adult EC Users - 20mg/mL, 5% Free-base | Behavioral Intentions for Continued Use | Use Product Regularly | 2.83 score on a scale | Standard Deviation 1.81 |
| Young Adult EC Users - 20mg/mL, 5% Free-base | Behavioral Intentions for Continued Use | Try Product Again | 3.73 score on a scale | Standard Deviation 2.01 |
| Young Adult EC Users - 20mg/mL, 5% Free-base | Behavioral Intentions for Continued Use | Purchase Product for Regular Use | 2.86 score on a scale | Standard Deviation 1.85 |
| Young Adult EC Users - 20mg/mL, 25% Free-base | Behavioral Intentions for Continued Use | Try Product Again | 3.88 score on a scale | Standard Deviation 1.93 |
| Young Adult EC Users - 20mg/mL, 25% Free-base | Behavioral Intentions for Continued Use | Use Product Regularly | 3.12 score on a scale | Standard Deviation 1.88 |
| Young Adult EC Users - 20mg/mL, 25% Free-base | Behavioral Intentions for Continued Use | Purchase Product for Regular Use | 2.95 score on a scale | Standard Deviation 1.8 |
| Young Adult EC Users - 20mg/mL, 45% Free-base | Behavioral Intentions for Continued Use | Purchase Product for Regular Use | 2.98 score on a scale | Standard Deviation 1.69 |
| Young Adult EC Users - 20mg/mL, 45% Free-base | Behavioral Intentions for Continued Use | Use Product Regularly | 3.05 score on a scale | Standard Deviation 1.77 |
| Young Adult EC Users - 20mg/mL, 45% Free-base | Behavioral Intentions for Continued Use | Try Product Again | 3.91 score on a scale | Standard Deviation 1.86 |
| Young Adult EC Users - 20mg/mL, 65% Free-base | Behavioral Intentions for Continued Use | Use Product Regularly | 2.76 score on a scale | Standard Deviation 1.7 |
| Young Adult EC Users - 20mg/mL, 65% Free-base | Behavioral Intentions for Continued Use | Purchase Product for Regular Use | 2.71 score on a scale | Standard Deviation 1.71 |
| Young Adult EC Users - 20mg/mL, 65% Free-base | Behavioral Intentions for Continued Use | Try Product Again | 3.74 score on a scale | Standard Deviation 1.79 |
| Young Adult EC Users - 20mg/mL, 85% Free-base | Behavioral Intentions for Continued Use | Purchase Product for Regular Use | 2.70 score on a scale | Standard Deviation 1.77 |
| Young Adult EC Users - 20mg/mL, 85% Free-base | Behavioral Intentions for Continued Use | Use Product Regularly | 2.77 score on a scale | Standard Deviation 1.8 |
| Young Adult EC Users - 20mg/mL, 85% Free-base | Behavioral Intentions for Continued Use | Try Product Again | 3.55 score on a scale | Standard Deviation 1.93 |
| Young Adult EC Users - 50mg/mL, 5% Free-base | Behavioral Intentions for Continued Use | Try Product Again | 3.74 score on a scale | Standard Deviation 1.98 |
| Young Adult EC Users - 50mg/mL, 5% Free-base | Behavioral Intentions for Continued Use | Use Product Regularly | 2.71 score on a scale | Standard Deviation 1.79 |
| Young Adult EC Users - 50mg/mL, 5% Free-base | Behavioral Intentions for Continued Use | Purchase Product for Regular Use | 2.64 score on a scale | Standard Deviation 1.73 |
| Young Adult EC Users - 50mg/mL, 25% Free-base | Behavioral Intentions for Continued Use | Try Product Again | 2.95 score on a scale | Standard Deviation 1.86 |
| Young Adult EC Users - 50mg/mL, 25% Free-base | Behavioral Intentions for Continued Use | Use Product Regularly | 2.27 score on a scale | Standard Deviation 1.71 |
| Young Adult EC Users - 50mg/mL, 25% Free-base | Behavioral Intentions for Continued Use | Purchase Product for Regular Use | 2.29 score on a scale | Standard Deviation 1.76 |
| Young Adult EC Users - 50mg/mL, 45% Free-base | Behavioral Intentions for Continued Use | Try Product Again | 3.00 score on a scale | Standard Deviation 1.74 |
| Young Adult EC Users - 50mg/mL, 45% Free-base | Behavioral Intentions for Continued Use | Purchase Product for Regular Use | 2.09 score on a scale | Standard Deviation 1.38 |
| Young Adult EC Users - 50mg/mL, 45% Free-base | Behavioral Intentions for Continued Use | Use Product Regularly | 2.03 score on a scale | Standard Deviation 1.37 |
| Young Adult EC Users - 50mg/mL, 65% Free-base | Behavioral Intentions for Continued Use | Try Product Again | 2.35 score on a scale | Standard Deviation 1.52 |
| Young Adult EC Users - 50mg/mL, 65% Free-base | Behavioral Intentions for Continued Use | Purchase Product for Regular Use | 1.64 score on a scale | Standard Deviation 1.25 |
| Young Adult EC Users - 50mg/mL, 65% Free-base | Behavioral Intentions for Continued Use | Use Product Regularly | 1.74 score on a scale | Standard Deviation 1.27 |
| Young Adult EC Users - 50mg/mL, 85% Free-base | Behavioral Intentions for Continued Use | Use Product Regularly | 1.52 score on a scale | Standard Deviation 1.27 |
| Young Adult EC Users - 50mg/mL, 85% Free-base | Behavioral Intentions for Continued Use | Purchase Product for Regular Use | 1.52 score on a scale | Standard Deviation 1.14 |
| Young Adult EC Users - 50mg/mL, 85% Free-base | Behavioral Intentions for Continued Use | Try Product Again | 1.94 score on a scale | Standard Deviation 1.38 |
| Older Adult Smokers - 20mg/mL, 5% Free-base | Behavioral Intentions for Continued Use | Try Product Again | 3.85 score on a scale | Standard Deviation 2.06 |
| Older Adult Smokers - 20mg/mL, 5% Free-base | Behavioral Intentions for Continued Use | Purchase Product for Regular Use | 3.21 score on a scale | Standard Deviation 1.94 |
| Older Adult Smokers - 20mg/mL, 5% Free-base | Behavioral Intentions for Continued Use | Use Product Regularly | 3.09 score on a scale | Standard Deviation 2 |
| Older Adult Smokers - 20mg/mL, 25% Free-base | Behavioral Intentions for Continued Use | Use Product Regularly | 3.02 score on a scale | Standard Deviation 1.99 |
| Older Adult Smokers - 20mg/mL, 25% Free-base | Behavioral Intentions for Continued Use | Try Product Again | 3.70 score on a scale | Standard Deviation 1.97 |
| Older Adult Smokers - 20mg/mL, 25% Free-base | Behavioral Intentions for Continued Use | Purchase Product for Regular Use | 3.06 score on a scale | Standard Deviation 1.98 |
| Older Adult Smokers - 20mg/mL, 45% Free-base | Behavioral Intentions for Continued Use | Use Product Regularly | 2.79 score on a scale | Standard Deviation 1.9 |
| Older Adult Smokers - 20mg/mL, 45% Free-base | Behavioral Intentions for Continued Use | Try Product Again | 3.44 score on a scale | Standard Deviation 1.92 |
| Older Adult Smokers - 20mg/mL, 45% Free-base | Behavioral Intentions for Continued Use | Purchase Product for Regular Use | 3.03 score on a scale | Standard Deviation 1.98 |
| Older Adult Smokers - 20mg/mL, 65% Free-base | Behavioral Intentions for Continued Use | Purchase Product for Regular Use | 3.11 score on a scale | Standard Deviation 2.04 |
| Older Adult Smokers - 20mg/mL, 65% Free-base | Behavioral Intentions for Continued Use | Use Product Regularly | 2.97 score on a scale | Standard Deviation 2.09 |
| Older Adult Smokers - 20mg/mL, 65% Free-base | Behavioral Intentions for Continued Use | Try Product Again | 3.80 score on a scale | Standard Deviation 2.04 |
| Older Adult Smokers - 20mg/mL, 85% Free-base | Behavioral Intentions for Continued Use | Purchase Product for Regular Use | 2.42 score on a scale | Standard Deviation 1.74 |
| Older Adult Smokers - 20mg/mL, 85% Free-base | Behavioral Intentions for Continued Use | Try Product Again | 2.88 score on a scale | Standard Deviation 1.83 |
| Older Adult Smokers - 20mg/mL, 85% Free-base | Behavioral Intentions for Continued Use | Use Product Regularly | 2.36 score on a scale | Standard Deviation 1.74 |
| Older Adult Smokers - 50mg/mL, 5% Free-base | Behavioral Intentions for Continued Use | Use Product Regularly | 2.85 score on a scale | Standard Deviation 1.76 |
| Older Adult Smokers - 50mg/mL, 5% Free-base | Behavioral Intentions for Continued Use | Purchase Product for Regular Use | 2.92 score on a scale | Standard Deviation 1.78 |
| Older Adult Smokers - 50mg/mL, 5% Free-base | Behavioral Intentions for Continued Use | Try Product Again | 3.44 score on a scale | Standard Deviation 1.76 |
| Older Adult Smokers - 50mg/mL, 25% Free-base | Behavioral Intentions for Continued Use | Purchase Product for Regular Use | 2.47 score on a scale | Standard Deviation 1.73 |
| Older Adult Smokers - 50mg/mL, 25% Free-base | Behavioral Intentions for Continued Use | Use Product Regularly | 2.44 score on a scale | Standard Deviation 1.81 |
| Older Adult Smokers - 50mg/mL, 25% Free-base | Behavioral Intentions for Continued Use | Try Product Again | 3.03 score on a scale | Standard Deviation 1.93 |
| Older Adult Smokers - 50mg/mL, 45% Free-base | Behavioral Intentions for Continued Use | Try Product Again | 2.74 score on a scale | Standard Deviation 1.78 |
| Older Adult Smokers - 50mg/mL, 45% Free-base | Behavioral Intentions for Continued Use | Purchase Product for Regular Use | 2.15 score on a scale | Standard Deviation 1.6 |
| Older Adult Smokers - 50mg/mL, 45% Free-base | Behavioral Intentions for Continued Use | Use Product Regularly | 2.14 score on a scale | Standard Deviation 1.65 |
| Older Adult Smokers - 50mg/mL, 65% Free-base | Behavioral Intentions for Continued Use | Try Product Again | 2.24 score on a scale | Standard Deviation 1.61 |
| Older Adult Smokers - 50mg/mL, 65% Free-base | Behavioral Intentions for Continued Use | Purchase Product for Regular Use | 1.91 score on a scale | Standard Deviation 1.49 |
| Older Adult Smokers - 50mg/mL, 65% Free-base | Behavioral Intentions for Continued Use | Use Product Regularly | 1.85 score on a scale | Standard Deviation 1.37 |
| Older Adult Smokers - 50mg/mL, 85% Free-base | Behavioral Intentions for Continued Use | Use Product Regularly | 1.76 score on a scale | Standard Deviation 1.35 |
| Older Adult Smokers - 50mg/mL, 85% Free-base | Behavioral Intentions for Continued Use | Try Product Again | 2.20 score on a scale | Standard Deviation 1.64 |
| Older Adult Smokers - 50mg/mL, 85% Free-base | Behavioral Intentions for Continued Use | Purchase Product for Regular Use | 1.74 score on a scale | Standard Deviation 1.33 |
Primary
Degree of Liking or Disliking of Sensations
Self-report measure completed following e-cigarette self-administration, using the Labeled Hedonic Scale (LHS). Scores range from -100 (most disliked imaginable) to 100 (most liked imaginable) with higher scores indicating a greater degree of liking.
Time frame: The outcome measure was assessed immediately after each vaping session. During each vaping session, participants took two puffs of each of the 10 study conditions within a single study visit lasting up to 3 hours.
Population: Participants who provided valid responses to the LHS item, LHS data was missing in 7 instances
| Arm | Measure | Value (MEAN) | Dispersion |
|---|---|---|---|
| Young Adult EC Users - 20mg/mL, 5% Free-base | Degree of Liking or Disliking of Sensations | 8.34 score on a scale | Standard Deviation 31.61 |
| Young Adult EC Users - 20mg/mL, 25% Free-base | Degree of Liking or Disliking of Sensations | 5.33 score on a scale | Standard Deviation 33.35 |
| Young Adult EC Users - 20mg/mL, 45% Free-base | Degree of Liking or Disliking of Sensations | 11.83 score on a scale | Standard Deviation 29.47 |
| Young Adult EC Users - 20mg/mL, 65% Free-base | Degree of Liking or Disliking of Sensations | 5.42 score on a scale | Standard Deviation 25.27 |
| Young Adult EC Users - 20mg/mL, 85% Free-base | Degree of Liking or Disliking of Sensations | 0.05 score on a scale | Standard Deviation 28.63 |
| Young Adult EC Users - 50mg/mL, 5% Free-base | Degree of Liking or Disliking of Sensations | 6.89 score on a scale | Standard Deviation 31.31 |
| Young Adult EC Users - 50mg/mL, 25% Free-base | Degree of Liking or Disliking of Sensations | -8.82 score on a scale | Standard Deviation 37.66 |
| Young Adult EC Users - 50mg/mL, 45% Free-base | Degree of Liking or Disliking of Sensations | -15.58 score on a scale | Standard Deviation 33.41 |
| Young Adult EC Users - 50mg/mL, 65% Free-base | Degree of Liking or Disliking of Sensations | -30.00 score on a scale | Standard Deviation 34.31 |
| Young Adult EC Users - 50mg/mL, 85% Free-base | Degree of Liking or Disliking of Sensations | -40.92 score on a scale | Standard Deviation 33.84 |
| Older Adult Smokers - 20mg/mL, 5% Free-base | Degree of Liking or Disliking of Sensations | 13.94 score on a scale | Standard Deviation 38.88 |
| Older Adult Smokers - 20mg/mL, 25% Free-base | Degree of Liking or Disliking of Sensations | 12.85 score on a scale | Standard Deviation 39.92 |
| Older Adult Smokers - 20mg/mL, 45% Free-base | Degree of Liking or Disliking of Sensations | 7.98 score on a scale | Standard Deviation 39.4 |
| Older Adult Smokers - 20mg/mL, 65% Free-base | Degree of Liking or Disliking of Sensations | 11.74 score on a scale | Standard Deviation 40.03 |
| Older Adult Smokers - 20mg/mL, 85% Free-base | Degree of Liking or Disliking of Sensations | -7.30 score on a scale | Standard Deviation 40.18 |
| Older Adult Smokers - 50mg/mL, 5% Free-base | Degree of Liking or Disliking of Sensations | 1.88 score on a scale | Standard Deviation 40 |
| Older Adult Smokers - 50mg/mL, 25% Free-base | Degree of Liking or Disliking of Sensations | -9.27 score on a scale | Standard Deviation 46.73 |
| Older Adult Smokers - 50mg/mL, 45% Free-base | Degree of Liking or Disliking of Sensations | -19.18 score on a scale | Standard Deviation 41.19 |
| Older Adult Smokers - 50mg/mL, 65% Free-base | Degree of Liking or Disliking of Sensations | -27.18 score on a scale | Standard Deviation 41.8 |
| Older Adult Smokers - 50mg/mL, 85% Free-base | Degree of Liking or Disliking of Sensations | -36.61 score on a scale | Standard Deviation 41.33 |
Primary
Intensity of Sensory Attributes
5-item self-report measure completed following e-cigarette self-administration, using the general Labeled Magnitude Scale (gLMS). Scores range from 0 (no sensation) to 100 (strongest imaginable) with higher scores indicating a greater sensation intensity.
Time frame: The outcome measure was assessed immediately after each vaping session. During each vaping session, participants took two puffs of each of the 10 study conditions within a single study visit lasting up to 3 hours.
Population: Participants who provided valid responses to the gLMS items; responses were missing in two instances
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Young Adult EC Users - 20mg/mL, 5% Free-base | Intensity of Sensory Attributes | Harshness | 12.48 score on a scale | Standard Deviation 13.95 |
| Young Adult EC Users - 20mg/mL, 5% Free-base | Intensity of Sensory Attributes | Smoothness | 29.82 score on a scale | Standard Deviation 25.14 |
| Young Adult EC Users - 20mg/mL, 5% Free-base | Intensity of Sensory Attributes | Bitterness | 11.50 score on a scale | Standard Deviation 13.32 |
| Young Adult EC Users - 20mg/mL, 5% Free-base | Intensity of Sensory Attributes | Throat Hit | 13.05 score on a scale | Standard Deviation 13.09 |
| Young Adult EC Users - 20mg/mL, 5% Free-base | Intensity of Sensory Attributes | Sweetness | 14.36 score on a scale | Standard Deviation 15.12 |
| Young Adult EC Users - 20mg/mL, 25% Free-base | Intensity of Sensory Attributes | Sweetness | 13.32 score on a scale | Standard Deviation 12.41 |
| Young Adult EC Users - 20mg/mL, 25% Free-base | Intensity of Sensory Attributes | Smoothness | 26.21 score on a scale | Standard Deviation 20.86 |
| Young Adult EC Users - 20mg/mL, 25% Free-base | Intensity of Sensory Attributes | Throat Hit | 13.03 score on a scale | Standard Deviation 11.66 |
| Young Adult EC Users - 20mg/mL, 25% Free-base | Intensity of Sensory Attributes | Bitterness | 10.67 score on a scale | Standard Deviation 11.18 |
| Young Adult EC Users - 20mg/mL, 25% Free-base | Intensity of Sensory Attributes | Harshness | 13.53 score on a scale | Standard Deviation 14.79 |
| Young Adult EC Users - 20mg/mL, 45% Free-base | Intensity of Sensory Attributes | Smoothness | 29.73 score on a scale | Standard Deviation 23.68 |
| Young Adult EC Users - 20mg/mL, 45% Free-base | Intensity of Sensory Attributes | Harshness | 13.02 score on a scale | Standard Deviation 13.84 |
| Young Adult EC Users - 20mg/mL, 45% Free-base | Intensity of Sensory Attributes | Throat Hit | 16.17 score on a scale | Standard Deviation 15 |
| Young Adult EC Users - 20mg/mL, 45% Free-base | Intensity of Sensory Attributes | Sweetness | 13.61 score on a scale | Standard Deviation 15.89 |
| Young Adult EC Users - 20mg/mL, 45% Free-base | Intensity of Sensory Attributes | Bitterness | 11.68 score on a scale | Standard Deviation 12.35 |
| Young Adult EC Users - 20mg/mL, 65% Free-base | Intensity of Sensory Attributes | Smoothness | 23.12 score on a scale | Standard Deviation 20 |
| Young Adult EC Users - 20mg/mL, 65% Free-base | Intensity of Sensory Attributes | Throat Hit | 17.53 score on a scale | Standard Deviation 15.83 |
| Young Adult EC Users - 20mg/mL, 65% Free-base | Intensity of Sensory Attributes | Harshness | 15.48 score on a scale | Standard Deviation 19.13 |
| Young Adult EC Users - 20mg/mL, 65% Free-base | Intensity of Sensory Attributes | Sweetness | 12.39 score on a scale | Standard Deviation 14.18 |
| Young Adult EC Users - 20mg/mL, 65% Free-base | Intensity of Sensory Attributes | Bitterness | 16.02 score on a scale | Standard Deviation 19.25 |
| Young Adult EC Users - 20mg/mL, 85% Free-base | Intensity of Sensory Attributes | Bitterness | 15.27 score on a scale | Standard Deviation 16.17 |
| Young Adult EC Users - 20mg/mL, 85% Free-base | Intensity of Sensory Attributes | Harshness | 18.14 score on a scale | Standard Deviation 18.26 |
| Young Adult EC Users - 20mg/mL, 85% Free-base | Intensity of Sensory Attributes | Smoothness | 23.71 score on a scale | Standard Deviation 17.35 |
| Young Adult EC Users - 20mg/mL, 85% Free-base | Intensity of Sensory Attributes | Sweetness | 11.58 score on a scale | Standard Deviation 12.08 |
| Young Adult EC Users - 20mg/mL, 85% Free-base | Intensity of Sensory Attributes | Throat Hit | 21.29 score on a scale | Standard Deviation 16.8 |
| Young Adult EC Users - 50mg/mL, 5% Free-base | Intensity of Sensory Attributes | Bitterness | 13.80 score on a scale | Standard Deviation 12.33 |
| Young Adult EC Users - 50mg/mL, 5% Free-base | Intensity of Sensory Attributes | Smoothness | 24.74 score on a scale | Standard Deviation 21.3 |
| Young Adult EC Users - 50mg/mL, 5% Free-base | Intensity of Sensory Attributes | Sweetness | 12.59 score on a scale | Standard Deviation 13.75 |
| Young Adult EC Users - 50mg/mL, 5% Free-base | Intensity of Sensory Attributes | Harshness | 16.44 score on a scale | Standard Deviation 14.75 |
| Young Adult EC Users - 50mg/mL, 5% Free-base | Intensity of Sensory Attributes | Throat Hit | 19.39 score on a scale | Standard Deviation 14.46 |
| Young Adult EC Users - 50mg/mL, 25% Free-base | Intensity of Sensory Attributes | Harshness | 28.70 score on a scale | Standard Deviation 21.76 |
| Young Adult EC Users - 50mg/mL, 25% Free-base | Intensity of Sensory Attributes | Sweetness | 11.27 score on a scale | Standard Deviation 14.62 |
| Young Adult EC Users - 50mg/mL, 25% Free-base | Intensity of Sensory Attributes | Smoothness | 19.20 score on a scale | Standard Deviation 18.6 |
| Young Adult EC Users - 50mg/mL, 25% Free-base | Intensity of Sensory Attributes | Throat Hit | 32.97 score on a scale | Standard Deviation 22.04 |
| Young Adult EC Users - 50mg/mL, 25% Free-base | Intensity of Sensory Attributes | Bitterness | 22.35 score on a scale | Standard Deviation 20.55 |
| Young Adult EC Users - 50mg/mL, 45% Free-base | Intensity of Sensory Attributes | Harshness | 40.41 score on a scale | Standard Deviation 25.62 |
| Young Adult EC Users - 50mg/mL, 45% Free-base | Intensity of Sensory Attributes | Bitterness | 25.26 score on a scale | Standard Deviation 22.19 |
| Young Adult EC Users - 50mg/mL, 45% Free-base | Intensity of Sensory Attributes | Throat Hit | 36.20 score on a scale | Standard Deviation 24.04 |
| Young Adult EC Users - 50mg/mL, 45% Free-base | Intensity of Sensory Attributes | Sweetness | 9.32 score on a scale | Standard Deviation 9.58 |
| Young Adult EC Users - 50mg/mL, 45% Free-base | Intensity of Sensory Attributes | Smoothness | 12.02 score on a scale | Standard Deviation 11.86 |
| Young Adult EC Users - 50mg/mL, 65% Free-base | Intensity of Sensory Attributes | Bitterness | 27.58 score on a scale | Standard Deviation 23.64 |
| Young Adult EC Users - 50mg/mL, 65% Free-base | Intensity of Sensory Attributes | Smoothness | 11.09 score on a scale | Standard Deviation 12.19 |
| Young Adult EC Users - 50mg/mL, 65% Free-base | Intensity of Sensory Attributes | Sweetness | 7.20 score on a scale | Standard Deviation 12.65 |
| Young Adult EC Users - 50mg/mL, 65% Free-base | Intensity of Sensory Attributes | Throat Hit | 45.77 score on a scale | Standard Deviation 27.57 |
| Young Adult EC Users - 50mg/mL, 65% Free-base | Intensity of Sensory Attributes | Harshness | 44.53 score on a scale | Standard Deviation 27.66 |
| Young Adult EC Users - 50mg/mL, 85% Free-base | Intensity of Sensory Attributes | Throat Hit | 53.39 score on a scale | Standard Deviation 26.26 |
| Young Adult EC Users - 50mg/mL, 85% Free-base | Intensity of Sensory Attributes | Smoothness | 7.59 score on a scale | Standard Deviation 9.33 |
| Young Adult EC Users - 50mg/mL, 85% Free-base | Intensity of Sensory Attributes | Harshness | 53.26 score on a scale | Standard Deviation 29.61 |
| Young Adult EC Users - 50mg/mL, 85% Free-base | Intensity of Sensory Attributes | Sweetness | 6.15 score on a scale | Standard Deviation 10.36 |
| Young Adult EC Users - 50mg/mL, 85% Free-base | Intensity of Sensory Attributes | Bitterness | 33.41 score on a scale | Standard Deviation 27.26 |
| Older Adult Smokers - 20mg/mL, 5% Free-base | Intensity of Sensory Attributes | Smoothness | 37.04 score on a scale | Standard Deviation 26.57 |
| Older Adult Smokers - 20mg/mL, 5% Free-base | Intensity of Sensory Attributes | Bitterness | 10.19 score on a scale | Standard Deviation 12.35 |
| Older Adult Smokers - 20mg/mL, 5% Free-base | Intensity of Sensory Attributes | Harshness | 14.33 score on a scale | Standard Deviation 17.77 |
| Older Adult Smokers - 20mg/mL, 5% Free-base | Intensity of Sensory Attributes | Throat Hit | 17.07 score on a scale | Standard Deviation 18.12 |
| Older Adult Smokers - 20mg/mL, 5% Free-base | Intensity of Sensory Attributes | Sweetness | 17.60 score on a scale | Standard Deviation 18.23 |
| Older Adult Smokers - 20mg/mL, 25% Free-base | Intensity of Sensory Attributes | Throat Hit | 21.64 score on a scale | Standard Deviation 22.48 |
| Older Adult Smokers - 20mg/mL, 25% Free-base | Intensity of Sensory Attributes | Sweetness | 19.29 score on a scale | Standard Deviation 20.34 |
| Older Adult Smokers - 20mg/mL, 25% Free-base | Intensity of Sensory Attributes | Bitterness | 13.39 score on a scale | Standard Deviation 16.61 |
| Older Adult Smokers - 20mg/mL, 25% Free-base | Intensity of Sensory Attributes | Smoothness | 35.79 score on a scale | Standard Deviation 25.53 |
| Older Adult Smokers - 20mg/mL, 25% Free-base | Intensity of Sensory Attributes | Harshness | 18.03 score on a scale | Standard Deviation 21.83 |
| Older Adult Smokers - 20mg/mL, 45% Free-base | Intensity of Sensory Attributes | Smoothness | 33.38 score on a scale | Standard Deviation 24.49 |
| Older Adult Smokers - 20mg/mL, 45% Free-base | Intensity of Sensory Attributes | Harshness | 18.76 score on a scale | Standard Deviation 22.65 |
| Older Adult Smokers - 20mg/mL, 45% Free-base | Intensity of Sensory Attributes | Throat Hit | 22.92 score on a scale | Standard Deviation 20.61 |
| Older Adult Smokers - 20mg/mL, 45% Free-base | Intensity of Sensory Attributes | Bitterness | 17.09 score on a scale | Standard Deviation 21.37 |
| Older Adult Smokers - 20mg/mL, 45% Free-base | Intensity of Sensory Attributes | Sweetness | 21.92 score on a scale | Standard Deviation 19.89 |
| Older Adult Smokers - 20mg/mL, 65% Free-base | Intensity of Sensory Attributes | Sweetness | 20.29 score on a scale | Standard Deviation 17.41 |
| Older Adult Smokers - 20mg/mL, 65% Free-base | Intensity of Sensory Attributes | Harshness | 18.24 score on a scale | Standard Deviation 19.73 |
| Older Adult Smokers - 20mg/mL, 65% Free-base | Intensity of Sensory Attributes | Throat Hit | 22.03 score on a scale | Standard Deviation 19.99 |
| Older Adult Smokers - 20mg/mL, 65% Free-base | Intensity of Sensory Attributes | Bitterness | 12.68 score on a scale | Standard Deviation 14.76 |
| Older Adult Smokers - 20mg/mL, 65% Free-base | Intensity of Sensory Attributes | Smoothness | 33.74 score on a scale | Standard Deviation 26.38 |
| Older Adult Smokers - 20mg/mL, 85% Free-base | Intensity of Sensory Attributes | Harshness | 27.88 score on a scale | Standard Deviation 27.77 |
| Older Adult Smokers - 20mg/mL, 85% Free-base | Intensity of Sensory Attributes | Sweetness | 13.82 score on a scale | Standard Deviation 14.36 |
| Older Adult Smokers - 20mg/mL, 85% Free-base | Intensity of Sensory Attributes | Smoothness | 25.22 score on a scale | Standard Deviation 23.31 |
| Older Adult Smokers - 20mg/mL, 85% Free-base | Intensity of Sensory Attributes | Bitterness | 15.73 score on a scale | Standard Deviation 17.58 |
| Older Adult Smokers - 20mg/mL, 85% Free-base | Intensity of Sensory Attributes | Throat Hit | 29.51 score on a scale | Standard Deviation 24.68 |
| Older Adult Smokers - 50mg/mL, 5% Free-base | Intensity of Sensory Attributes | Harshness | 27.03 score on a scale | Standard Deviation 24.99 |
| Older Adult Smokers - 50mg/mL, 5% Free-base | Intensity of Sensory Attributes | Throat Hit | 26.82 score on a scale | Standard Deviation 21.12 |
| Older Adult Smokers - 50mg/mL, 5% Free-base | Intensity of Sensory Attributes | Bitterness | 20.70 score on a scale | Standard Deviation 25.12 |
| Older Adult Smokers - 50mg/mL, 5% Free-base | Intensity of Sensory Attributes | Sweetness | 18.44 score on a scale | Standard Deviation 17.53 |
| Older Adult Smokers - 50mg/mL, 5% Free-base | Intensity of Sensory Attributes | Smoothness | 27.06 score on a scale | Standard Deviation 21.31 |
| Older Adult Smokers - 50mg/mL, 25% Free-base | Intensity of Sensory Attributes | Sweetness | 12.74 score on a scale | Standard Deviation 13.77 |
| Older Adult Smokers - 50mg/mL, 25% Free-base | Intensity of Sensory Attributes | Throat Hit | 34.73 score on a scale | Standard Deviation 23.18 |
| Older Adult Smokers - 50mg/mL, 25% Free-base | Intensity of Sensory Attributes | Smoothness | 22.52 score on a scale | Standard Deviation 21.38 |
| Older Adult Smokers - 50mg/mL, 25% Free-base | Intensity of Sensory Attributes | Harshness | 36.36 score on a scale | Standard Deviation 27.28 |
| Older Adult Smokers - 50mg/mL, 25% Free-base | Intensity of Sensory Attributes | Bitterness | 22.11 score on a scale | Standard Deviation 22.27 |
| Older Adult Smokers - 50mg/mL, 45% Free-base | Intensity of Sensory Attributes | Throat Hit | 41.21 score on a scale | Standard Deviation 20.75 |
| Older Adult Smokers - 50mg/mL, 45% Free-base | Intensity of Sensory Attributes | Smoothness | 19.44 score on a scale | Standard Deviation 21.9 |
| Older Adult Smokers - 50mg/mL, 45% Free-base | Intensity of Sensory Attributes | Sweetness | 14.33 score on a scale | Standard Deviation 17.41 |
| Older Adult Smokers - 50mg/mL, 45% Free-base | Intensity of Sensory Attributes | Harshness | 42.77 score on a scale | Standard Deviation 24.66 |
| Older Adult Smokers - 50mg/mL, 45% Free-base | Intensity of Sensory Attributes | Bitterness | 28.48 score on a scale | Standard Deviation 23.89 |
| Older Adult Smokers - 50mg/mL, 65% Free-base | Intensity of Sensory Attributes | Bitterness | 27.88 score on a scale | Standard Deviation 25.39 |
| Older Adult Smokers - 50mg/mL, 65% Free-base | Intensity of Sensory Attributes | Throat Hit | 46.15 score on a scale | Standard Deviation 27.85 |
| Older Adult Smokers - 50mg/mL, 65% Free-base | Intensity of Sensory Attributes | Harshness | 47.42 score on a scale | Standard Deviation 29.32 |
| Older Adult Smokers - 50mg/mL, 65% Free-base | Intensity of Sensory Attributes | Sweetness | 12.21 score on a scale | Standard Deviation 15.75 |
| Older Adult Smokers - 50mg/mL, 65% Free-base | Intensity of Sensory Attributes | Smoothness | 20.74 score on a scale | Standard Deviation 25.11 |
| Older Adult Smokers - 50mg/mL, 85% Free-base | Intensity of Sensory Attributes | Smoothness | 13.92 score on a scale | Standard Deviation 17.78 |
| Older Adult Smokers - 50mg/mL, 85% Free-base | Intensity of Sensory Attributes | Sweetness | 10.65 score on a scale | Standard Deviation 14.5 |
| Older Adult Smokers - 50mg/mL, 85% Free-base | Intensity of Sensory Attributes | Bitterness | 31.55 score on a scale | Standard Deviation 25.81 |
| Older Adult Smokers - 50mg/mL, 85% Free-base | Intensity of Sensory Attributes | Throat Hit | 53.74 score on a scale | Standard Deviation 25.87 |
| Older Adult Smokers - 50mg/mL, 85% Free-base | Intensity of Sensory Attributes | Harshness | 52.77 score on a scale | Standard Deviation 29 |
Secondary
Subjective Appeal
12-item modified Cigarette Evaluation Questionnaire (mCEQ) completed following e-cigarette self-administration to assess subjective responses to the e-cigarettes. The 12-item mCEQ includes five subscales: Smoking Satisfaction, Psychological Reward, Aversion, Enjoyment of Respiratory Tract Sensations, and Craving Reduction, with items rated from 1 (not at all) to 7 (extremely likely). Scores for each subscale are calculated as the mean of the individual item responses or the single item. Higher scores indicate greater intensity on that scale.
Time frame: The outcome measure was assessed immediately after each vaping session. During each vaping session, participants took two puffs of each of the 10 study conditions within a single study visit lasting up to 3 hours.
| Arm | Measure | Group | Value (MEAN) | Dispersion |
|---|---|---|---|---|
| Young Adult EC Users - 20mg/mL, 5% Free-base | Subjective Appeal | Craving Reduction | 2.23 score on a scale | Standard Deviation 1.49 |
| Young Adult EC Users - 20mg/mL, 5% Free-base | Subjective Appeal | Psychological Reward | 2.06 score on a scale | Standard Deviation 1.07 |
| Young Adult EC Users - 20mg/mL, 5% Free-base | Subjective Appeal | Aversion | 1.30 score on a scale | Standard Deviation 0.48 |
| Young Adult EC Users - 20mg/mL, 5% Free-base | Subjective Appeal | Enjoyment of Respiratory Tract Sensations | 2.88 score on a scale | Standard Deviation 1.55 |
| Young Adult EC Users - 20mg/mL, 5% Free-base | Subjective Appeal | Satisfaction | 3.19 score on a scale | Standard Deviation 1.63 |
| Young Adult EC Users - 20mg/mL, 25% Free-base | Subjective Appeal | Satisfaction | 3.21 score on a scale | Standard Deviation 1.27 |
| Young Adult EC Users - 20mg/mL, 25% Free-base | Subjective Appeal | Enjoyment of Respiratory Tract Sensations | 3.15 score on a scale | Standard Deviation 1.38 |
| Young Adult EC Users - 20mg/mL, 25% Free-base | Subjective Appeal | Aversion | 1.27 score on a scale | Standard Deviation 0.45 |
| Young Adult EC Users - 20mg/mL, 25% Free-base | Subjective Appeal | Psychological Reward | 2.19 score on a scale | Standard Deviation 1.08 |
| Young Adult EC Users - 20mg/mL, 25% Free-base | Subjective Appeal | Craving Reduction | 2.53 score on a scale | Standard Deviation 1.61 |
| Young Adult EC Users - 20mg/mL, 45% Free-base | Subjective Appeal | Satisfaction | 3.20 score on a scale | Standard Deviation 1.32 |
| Young Adult EC Users - 20mg/mL, 45% Free-base | Subjective Appeal | Aversion | 1.33 score on a scale | Standard Deviation 0.55 |
| Young Adult EC Users - 20mg/mL, 45% Free-base | Subjective Appeal | Craving Reduction | 2.68 score on a scale | Standard Deviation 1.65 |
| Young Adult EC Users - 20mg/mL, 45% Free-base | Subjective Appeal | Enjoyment of Respiratory Tract Sensations | 3.03 score on a scale | Standard Deviation 1.38 |
| Young Adult EC Users - 20mg/mL, 45% Free-base | Subjective Appeal | Psychological Reward | 2.27 score on a scale | Standard Deviation 1.1 |
| Young Adult EC Users - 20mg/mL, 65% Free-base | Subjective Appeal | Satisfaction | 3.09 score on a scale | Standard Deviation 1.23 |
| Young Adult EC Users - 20mg/mL, 65% Free-base | Subjective Appeal | Enjoyment of Respiratory Tract Sensations | 2.88 score on a scale | Standard Deviation 1.27 |
| Young Adult EC Users - 20mg/mL, 65% Free-base | Subjective Appeal | Craving Reduction | 2.50 score on a scale | Standard Deviation 1.65 |
| Young Adult EC Users - 20mg/mL, 65% Free-base | Subjective Appeal | Aversion | 1.27 score on a scale | Standard Deviation 0.6 |
| Young Adult EC Users - 20mg/mL, 65% Free-base | Subjective Appeal | Psychological Reward | 2.22 score on a scale | Standard Deviation 1.11 |
| Young Adult EC Users - 20mg/mL, 85% Free-base | Subjective Appeal | Enjoyment of Respiratory Tract Sensations | 2.85 score on a scale | Standard Deviation 1.32 |
| Young Adult EC Users - 20mg/mL, 85% Free-base | Subjective Appeal | Satisfaction | 2.88 score on a scale | Standard Deviation 1.32 |
| Young Adult EC Users - 20mg/mL, 85% Free-base | Subjective Appeal | Craving Reduction | 2.70 score on a scale | Standard Deviation 1.61 |
| Young Adult EC Users - 20mg/mL, 85% Free-base | Subjective Appeal | Psychological Reward | 2.22 score on a scale | Standard Deviation 1.16 |
| Young Adult EC Users - 20mg/mL, 85% Free-base | Subjective Appeal | Aversion | 1.31 score on a scale | Standard Deviation 0.65 |
| Young Adult EC Users - 50mg/mL, 5% Free-base | Subjective Appeal | Aversion | 1.58 score on a scale | Standard Deviation 0.88 |
| Young Adult EC Users - 50mg/mL, 5% Free-base | Subjective Appeal | Satisfaction | 3.13 score on a scale | Standard Deviation 1.39 |
| Young Adult EC Users - 50mg/mL, 5% Free-base | Subjective Appeal | Enjoyment of Respiratory Tract Sensations | 2.98 score on a scale | Standard Deviation 1.39 |
| Young Adult EC Users - 50mg/mL, 5% Free-base | Subjective Appeal | Psychological Reward | 2.30 score on a scale | Standard Deviation 1.18 |
| Young Adult EC Users - 50mg/mL, 5% Free-base | Subjective Appeal | Craving Reduction | 2.92 score on a scale | Standard Deviation 1.71 |
| Young Adult EC Users - 50mg/mL, 25% Free-base | Subjective Appeal | Craving Reduction | 2.67 score on a scale | Standard Deviation 1.66 |
| Young Adult EC Users - 50mg/mL, 25% Free-base | Subjective Appeal | Aversion | 1.53 score on a scale | Standard Deviation 0.74 |
| Young Adult EC Users - 50mg/mL, 25% Free-base | Subjective Appeal | Psychological Reward | 2.18 score on a scale | Standard Deviation 1.07 |
| Young Adult EC Users - 50mg/mL, 25% Free-base | Subjective Appeal | Enjoyment of Respiratory Tract Sensations | 2.52 score on a scale | Standard Deviation 1.45 |
| Young Adult EC Users - 50mg/mL, 25% Free-base | Subjective Appeal | Satisfaction | 2.53 score on a scale | Standard Deviation 1.3 |
| Young Adult EC Users - 50mg/mL, 45% Free-base | Subjective Appeal | Enjoyment of Respiratory Tract Sensations | 2.30 score on a scale | Standard Deviation 1.29 |
| Young Adult EC Users - 50mg/mL, 45% Free-base | Subjective Appeal | Craving Reduction | 2.42 score on a scale | Standard Deviation 1.55 |
| Young Adult EC Users - 50mg/mL, 45% Free-base | Subjective Appeal | Satisfaction | 2.36 score on a scale | Standard Deviation 1.24 |
| Young Adult EC Users - 50mg/mL, 45% Free-base | Subjective Appeal | Psychological Reward | 2.09 score on a scale | Standard Deviation 0.99 |
| Young Adult EC Users - 50mg/mL, 45% Free-base | Subjective Appeal | Aversion | 1.56 score on a scale | Standard Deviation 0.76 |
| Young Adult EC Users - 50mg/mL, 65% Free-base | Subjective Appeal | Psychological Reward | 2.12 score on a scale | Standard Deviation 1.07 |
| Young Adult EC Users - 50mg/mL, 65% Free-base | Subjective Appeal | Enjoyment of Respiratory Tract Sensations | 1.95 score on a scale | Standard Deviation 1.26 |
| Young Adult EC Users - 50mg/mL, 65% Free-base | Subjective Appeal | Aversion | 1.59 score on a scale | Standard Deviation 0.8 |
| Young Adult EC Users - 50mg/mL, 65% Free-base | Subjective Appeal | Satisfaction | 1.92 score on a scale | Standard Deviation 1.01 |
| Young Adult EC Users - 50mg/mL, 65% Free-base | Subjective Appeal | Craving Reduction | 2.26 score on a scale | Standard Deviation 1.46 |
| Young Adult EC Users - 50mg/mL, 85% Free-base | Subjective Appeal | Aversion | 1.68 score on a scale | Standard Deviation 0.93 |
| Young Adult EC Users - 50mg/mL, 85% Free-base | Subjective Appeal | Psychological Reward | 1.85 score on a scale | Standard Deviation 0.72 |
| Young Adult EC Users - 50mg/mL, 85% Free-base | Subjective Appeal | Satisfaction | 1.57 score on a scale | Standard Deviation 0.74 |
| Young Adult EC Users - 50mg/mL, 85% Free-base | Subjective Appeal | Craving Reduction | 2.21 score on a scale | Standard Deviation 1.6 |
| Young Adult EC Users - 50mg/mL, 85% Free-base | Subjective Appeal | Enjoyment of Respiratory Tract Sensations | 1.56 score on a scale | Standard Deviation 0.98 |
| Older Adult Smokers - 20mg/mL, 5% Free-base | Subjective Appeal | Satisfaction | 3.48 score on a scale | Standard Deviation 1.68 |
| Older Adult Smokers - 20mg/mL, 5% Free-base | Subjective Appeal | Psychological Reward | 2.30 score on a scale | Standard Deviation 1.32 |
| Older Adult Smokers - 20mg/mL, 5% Free-base | Subjective Appeal | Aversion | 1.28 score on a scale | Standard Deviation 0.57 |
| Older Adult Smokers - 20mg/mL, 5% Free-base | Subjective Appeal | Enjoyment of Respiratory Tract Sensations | 3.31 score on a scale | Standard Deviation 1.72 |
| Older Adult Smokers - 20mg/mL, 5% Free-base | Subjective Appeal | Craving Reduction | 2.78 score on a scale | Standard Deviation 1.54 |
| Older Adult Smokers - 20mg/mL, 25% Free-base | Subjective Appeal | Psychological Reward | 2.37 score on a scale | Standard Deviation 1.38 |
| Older Adult Smokers - 20mg/mL, 25% Free-base | Subjective Appeal | Aversion | 1.33 score on a scale | Standard Deviation 0.7 |
| Older Adult Smokers - 20mg/mL, 25% Free-base | Subjective Appeal | Craving Reduction | 2.91 score on a scale | Standard Deviation 1.71 |
| Older Adult Smokers - 20mg/mL, 25% Free-base | Subjective Appeal | Satisfaction | 3.38 score on a scale | Standard Deviation 1.77 |
| Older Adult Smokers - 20mg/mL, 25% Free-base | Subjective Appeal | Enjoyment of Respiratory Tract Sensations | 3.30 score on a scale | Standard Deviation 1.87 |
| Older Adult Smokers - 20mg/mL, 45% Free-base | Subjective Appeal | Satisfaction | 3.26 score on a scale | Standard Deviation 1.61 |
| Older Adult Smokers - 20mg/mL, 45% Free-base | Subjective Appeal | Enjoyment of Respiratory Tract Sensations | 3.14 score on a scale | Standard Deviation 1.73 |
| Older Adult Smokers - 20mg/mL, 45% Free-base | Subjective Appeal | Aversion | 1.33 score on a scale | Standard Deviation 0.65 |
| Older Adult Smokers - 20mg/mL, 45% Free-base | Subjective Appeal | Psychological Reward | 2.22 score on a scale | Standard Deviation 1.09 |
| Older Adult Smokers - 20mg/mL, 45% Free-base | Subjective Appeal | Craving Reduction | 2.76 score on a scale | Standard Deviation 1.55 |
| Older Adult Smokers - 20mg/mL, 65% Free-base | Subjective Appeal | Craving Reduction | 3.02 score on a scale | Standard Deviation 1.53 |
| Older Adult Smokers - 20mg/mL, 65% Free-base | Subjective Appeal | Psychological Reward | 2.38 score on a scale | Standard Deviation 1.28 |
| Older Adult Smokers - 20mg/mL, 65% Free-base | Subjective Appeal | Satisfaction | 3.40 score on a scale | Standard Deviation 1.67 |
| Older Adult Smokers - 20mg/mL, 65% Free-base | Subjective Appeal | Aversion | 1.22 score on a scale | Standard Deviation 0.53 |
| Older Adult Smokers - 20mg/mL, 65% Free-base | Subjective Appeal | Enjoyment of Respiratory Tract Sensations | 3.26 score on a scale | Standard Deviation 1.77 |
| Older Adult Smokers - 20mg/mL, 85% Free-base | Subjective Appeal | Psychological Reward | 2.00 score on a scale | Standard Deviation 1.1 |
| Older Adult Smokers - 20mg/mL, 85% Free-base | Subjective Appeal | Aversion | 1.43 score on a scale | Standard Deviation 0.84 |
| Older Adult Smokers - 20mg/mL, 85% Free-base | Subjective Appeal | Enjoyment of Respiratory Tract Sensations | 2.58 score on a scale | Standard Deviation 1.64 |
| Older Adult Smokers - 20mg/mL, 85% Free-base | Subjective Appeal | Satisfaction | 2.75 score on a scale | Standard Deviation 1.64 |
| Older Adult Smokers - 20mg/mL, 85% Free-base | Subjective Appeal | Craving Reduction | 2.67 score on a scale | Standard Deviation 1.54 |
| Older Adult Smokers - 50mg/mL, 5% Free-base | Subjective Appeal | Psychological Reward | 2.20 score on a scale | Standard Deviation 1.12 |
| Older Adult Smokers - 50mg/mL, 5% Free-base | Subjective Appeal | Enjoyment of Respiratory Tract Sensations | 3.17 score on a scale | Standard Deviation 1.71 |
| Older Adult Smokers - 50mg/mL, 5% Free-base | Subjective Appeal | Craving Reduction | 3.00 score on a scale | Standard Deviation 1.44 |
| Older Adult Smokers - 50mg/mL, 5% Free-base | Subjective Appeal | Aversion | 1.48 score on a scale | Standard Deviation 0.82 |
| Older Adult Smokers - 50mg/mL, 5% Free-base | Subjective Appeal | Satisfaction | 3.16 score on a scale | Standard Deviation 1.47 |
| Older Adult Smokers - 50mg/mL, 25% Free-base | Subjective Appeal | Aversion | 1.33 score on a scale | Standard Deviation 0.71 |
| Older Adult Smokers - 50mg/mL, 25% Free-base | Subjective Appeal | Psychological Reward | 2.10 score on a scale | Standard Deviation 1.05 |
| Older Adult Smokers - 50mg/mL, 25% Free-base | Subjective Appeal | Enjoyment of Respiratory Tract Sensations | 2.62 score on a scale | Standard Deviation 1.54 |
| Older Adult Smokers - 50mg/mL, 25% Free-base | Subjective Appeal | Craving Reduction | 2.65 score on a scale | Standard Deviation 1.55 |
| Older Adult Smokers - 50mg/mL, 25% Free-base | Subjective Appeal | Satisfaction | 2.71 score on a scale | Standard Deviation 1.48 |
| Older Adult Smokers - 50mg/mL, 45% Free-base | Subjective Appeal | Craving Reduction | 2.44 score on a scale | Standard Deviation 1.51 |
| Older Adult Smokers - 50mg/mL, 45% Free-base | Subjective Appeal | Enjoyment of Respiratory Tract Sensations | 2.03 score on a scale | Standard Deviation 1.58 |
| Older Adult Smokers - 50mg/mL, 45% Free-base | Subjective Appeal | Satisfaction | 2.34 score on a scale | Standard Deviation 1.52 |
| Older Adult Smokers - 50mg/mL, 45% Free-base | Subjective Appeal | Psychological Reward | 1.97 score on a scale | Standard Deviation 1.15 |
| Older Adult Smokers - 50mg/mL, 45% Free-base | Subjective Appeal | Aversion | 1.42 score on a scale | Standard Deviation 0.75 |
| Older Adult Smokers - 50mg/mL, 65% Free-base | Subjective Appeal | Aversion | 1.55 score on a scale | Standard Deviation 0.92 |
| Older Adult Smokers - 50mg/mL, 65% Free-base | Subjective Appeal | Psychological Reward | 1.76 score on a scale | Standard Deviation 0.83 |
| Older Adult Smokers - 50mg/mL, 65% Free-base | Subjective Appeal | Enjoyment of Respiratory Tract Sensations | 2.00 score on a scale | Standard Deviation 1.39 |
| Older Adult Smokers - 50mg/mL, 65% Free-base | Subjective Appeal | Satisfaction | 2.12 score on a scale | Standard Deviation 1.32 |
| Older Adult Smokers - 50mg/mL, 65% Free-base | Subjective Appeal | Craving Reduction | 2.26 score on a scale | Standard Deviation 1.38 |
| Older Adult Smokers - 50mg/mL, 85% Free-base | Subjective Appeal | Satisfaction | 1.96 score on a scale | Standard Deviation 1.31 |
| Older Adult Smokers - 50mg/mL, 85% Free-base | Subjective Appeal | Craving Reduction | 2.32 score on a scale | Standard Deviation 1.37 |
| Older Adult Smokers - 50mg/mL, 85% Free-base | Subjective Appeal | Enjoyment of Respiratory Tract Sensations | 1.86 score on a scale | Standard Deviation 1.37 |
| Older Adult Smokers - 50mg/mL, 85% Free-base | Subjective Appeal | Psychological Reward | 1.93 score on a scale | Standard Deviation 1.09 |
| Older Adult Smokers - 50mg/mL, 85% Free-base | Subjective Appeal | Aversion | 1.48 score on a scale | Standard Deviation 0.8 |