Predisposing Factors for Post-stroke Epilepsy

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05864547

Acronym

PRESTEP

Enrollment

Registered

2023-05-18

Start date

2023-05-08

Completion date

2030-12-01

Last updated

2026-07-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Epilepsy, Post Stroke Epilepsy, Seizures, Stroke

Keywords

Cerebrovascular Disorders, Brain Diseases, Central Nervous System Diseases, Nervous System Disorders, Vascular Diseases

Brief summary

The goal of this observational study is to learn about epilepsy after a stroke (post-stroke epilepsy). The main questions it aims to answer are: * What make some patients develop epilepsy after a stroke? * Does sleep have an impact on the development of post-stroke epilepsy? Participants will undergo: * Electroencephalography (EEG) * Magnetic resonance imaging (MRI) * Polysomnography (only patients) Blood tests will also be taken. The patient group will be compared to the healthy controls. Researchers will also look into medical records of stroke patients hospitalized at St. Olavs hospital and collect relevant information.

Detailed description

This study aims to study risk factors and clinical factors which might contribute to the development of post-stroke epilepsy. Researchers will look at the volume and size of the stroke-induced brain lesions and analyze inflammation markers. Patients and controls will undergo EEG and MRI. The correlations between sleep and epilepsy after a stroke will also be investigated through polysomnography. Relevant information about for instance age, comorbidities and NIHSS will be collected. Researchers will also collect relevant information from medical records of stroke patients hospitalized at St. Olavs hospital.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to 85 Years

Healthy volunteers

Yes

Inclusion criteria

* First time stroke patients with capacity to consent, admitted to the stroke unit at St. Olavs hospital. * Modified Rankin Scale (mRS) ≤ 2 before the stroke

Exclusion criteria

* Previous stroke or brain surgery * Traumatic brain injuries * Neurodegenerative diseases * Brain tumors * Epilepsy before the stroke * Hydrocephalus * Aphasia * Serious psychiatric disorders * MRI incompatibility and claustrophobia

Design outcomes

Primary

Measure	Time frame	Description
Post-stroke epilepsy	6 months	Minimum one documented case of post-stroke epilepsy after the stroke

Secondary

Measure	Time frame	Description
Acute symptomatic seizure	14 days	Minimum one documented case of acute symptomatic seizure with epileptogenic activity recorded with EEG

Countries

Norway

Contacts

CONTACTAxel Sandvig, PhD prof

axel.sandvig@ntnu.no+47 47333042

PRINCIPAL_INVESTIGATORAxel Sandvig, PhD prof

Norwegian Science and Technology University

Outcome results