Sedation and Analgesia
Conditions
Keywords
Radial Artery Cannulation, Novice Operators
Brief summary
The aim of this study is to conduct a prospective, single-center randomized controlled study to investigate the effect of mild midazolam combined with sufentanil on radial artery cannulation in novice operators.
Detailed description
outcome: patients discomfort，visual analogue scale，First-attempt success rate，the success rate of radial artery cannulation within 10 minutes, Complication rate
Interventions
DRUGmild sedation and analgesia
Intravenous injection of 0.1ug/kg sufentanil and 0.03mg/kg midazolam for sedation and analgesia before radial artery cannulation
DRUGcontrol
ntravenous injection of an equivalent volume of saline before radial artery cannulation.
Sponsors
Affiliated Hospital of Jiaxing University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
20 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Patients who required arterial cannulation for continuous blood pressure monitoring * Aged \>20years * ASA physical status of 1-3 * BMI 18-28kg/m2 * All patients agreed to participate in this study at the time of recruitment and signed an informed consent form.
Exclusion criteria
* a positive Allen's test * infection at the puncture site * coagulation disorders; arterial diseases (such as Raynaud's disease or thromboangiitis obliterans) * use of vasoactive drugs within 30 minutes before measurement during the study * patients with arterial abnormalities and bends; hemorrhagic shock * arterial atherosclerosis; radial artery puncture within the past 30 days * chronic use of opioid or benzodiazepine drugs * and known allergies or adverse reactions to benzodiazepines or opioids.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Overall success rate | During radial artery cannulation (up to 1 hour) | success rate of puncture and catheter placement within 10 minutes. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| patients discomfort | During radial artery cannulation (up to 1 hour) | 0 corresponding to no anxious, 1 corresponding to mildly anxious, 2 corresponding to moderately anxious and 3 corresponding to very anxious |
| visual analogue scale | During radial artery cannulation (up to 1 hour) | ranging from 0 to 10 was emplyed to assess pain intensity |
| First-attempt success rate | During radial artery cannulation (up to 1 hour) | Success at the first skin puncture |
| Complication rate | postoperative 1 day and 3 day | Hematoma, Distal ischemia, Spasm accessed by ultrasound |
Countries
China
Outcome results
None listed