Resistance Training With Blood Flow Restriction

Resistance Training With Blood Flow Restriction for the Lower Extremity Muscles

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05863039

Enrollment

Registered

2023-05-17

Start date

2022-11-01

Completion date

2026-04-27

Last updated

2026-05-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Healthy

Keywords

resistance training, strength training, blood flow restriction, motor units, body composition

Brief summary

Blood flow restriction associated with resistance training is suggested to potentiate increases in muscular strength and hypertrophy. This study will compare the effects of resistance training associated with blood flow restriction with a regular resistance training program. Findings of this project will provide important information regarding a promising intervention to potentiate muscle performance.

Detailed description

The purpose of this study is to determine alterations in motor unit behavior of the tibialis anterior muscles after a resistance exercise program associated with blood flow restriction. Our working hypothesis is that blood flow restriction to working muscles will induce greater changes in muscle activation, lean mass and muscle size compared with a training at same intensity without blood flow restriction.

Interventions

OTHERBlood flow restriction

Strength training of the lower leg muscles using blood flow restriction

OTHERRegular training type 1

Strength training of the lower leg muscles using high loads

OTHERRegular training type 2

Strength training of the lower leg muscles using low loads

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

BASIC_SCIENCE

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 50 Years

Healthy volunteers

Yes

Exclusion criteria

* presence of neurological diseases, * presence of metal implants or joint replacement * any restriction to perform physical activity * pregnancy

Design outcomes

Primary

Measure	Time frame	Description
Force	10 sessions (up to 6 weeks)	Force of the lower leg muscles using a custom made ergometer

Secondary

Measure	Time frame	Description
Body composition	Start and end of the protocol	dual x-ray absorptiometry (DEXA) will be used to assess body composition

Countries

United States

Contacts

PRINCIPAL_INVESTIGATORHugo Pereira, PhD

University of Oklahoma

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: May 2, 2026