Amyloidosis
Conditions
Keywords
respiratory amyloidosis, proteomic analysis
Brief summary
The B-AR project is based on a retrospective analysis of amyloidosis typing and the identification of their amylogenic protein.This work should be able to unite many clinicians, including pulmonologists and pathologists around a rare disease that still suffers from insufficient data.
Detailed description
The B-AR study will highlight the interest of proteomic analysis of amyloidosis compared to their identification by immunostaining. The objective is to reduce diagnostic wandering and to improve patient management. The typing of respiratory amyloidosis will allow a better characterization of the disease and thus, to propose a dedicated therapeutic management.
Interventions
None listed
Sponsors
Assistance Publique - Hôpitaux de Paris
Study design
Observational model
CASE_ONLY
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adult patient \> to 18 years with amyloidosis on a histological sample of the tracheobronchial or pulmonary tree.
Exclusion criteria
* Subject receiving state medical aid * Subject deprived of freedom, or under a legal protective measure (example: patients under guardianship or curators)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of cases with identification of the amylogenic protein in respiratory amyloidosis. | 1 day (at inclusion) | Identification of amylogenic protein by Proteomic Analysis Based on Tandem Mass Spectrometry on histological sample of the tracheobronchial or pulmonary tree. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Distribution and severity of amyloidosis | 1 day (at inclusion) | association between typing and respiratory involvement |
Contacts
Primary ContactYurdagül UZUNHAN, Pr,MD, PhD
Backup ContactMagali COLOMBAT, MD PhD
Outcome results
None listed