Dietary Habits
Conditions
Keywords
Glucose tolerance, Diet-induced thermogenesis, Fat tolerance
Brief summary
The goal of this clinical trial is to test whether food timing impacts metabolic health in healthy participants. Participants will: * complete 2 inpatient stays * be provided with test meals * have frequent blood draws
Detailed description
The investigators aim to investigate the influence of different food timing, without changing 24-h caloric and nutrient intake, on glucose and fat tolerance and energy expenditure in healthy people on a simulated day or night shift.
Interventions
BEHAVIORALDay shift protocol - Diet order A-B
Research participants will be assigned to day shift condition and Diet A-B order condition.
BEHAVIORALDay shift protocol - Diet order B-A
Research participants will be assigned to day shift condition and Diet B-A order condition.
BEHAVIORALNight shift protocol - Diet order A-B
Research participants will be assigned to simulated night shift condition and Diet A-B order condition.
BEHAVIORALNight shift protocol - Diet order B-A
Research participants will be assigned to simulated night shift condition and Diet B-A order condition.
Sponsors
Brigham and Women's Hospital
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 45 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy with no acute or chronic medical and psychiatric disorders * BMI: 18.5-29.9 kg/m2
Exclusion criteria
* Smokers, current tobacco or e-cigarette use * Drug or alcohol dependency * Pregnant
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Difference in glucose tolerance between Meal Conditions and Shift Work | 24 hours | Glucose incremental area under the curve (AUC) from mixed meal tests |
| Difference in diet-induced thermogenesis between Meal Conditions and Shift Work | 24 hours | Postprandial energy expenditure incremental area under the curve (AUC) from mixed meal tests |
| Difference in plasma triglyceride level between Meal Conditions and Shift Work | 24 hours | Triglyceride area under the curve (AUC) over 24 hours |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Difference in postprandial incretin level between Meal Conditions and Shift Work | 24 hours | Incretin incremental area under the curve (AUC) from mixed meal tests |
| Difference in insulin sensitivity between Meal Conditions and Shift Work | 24 hours | Insulin sensitivity index derived from Oral Minimal Model |
| Difference in plasma free fatty acids level between Meal Conditions and Shift Work | 24 hours | Free fatty acids area under the curve (AUC) over 24 hours |
| Difference in substrate oxidation between Meal Conditions and Shift Work | 24 hours | Postprandial substrate oxidation incremental area under the curve (AUC) from mixed meal tests |
| Difference in beta-cell function between Meal Conditions and Shift Work | 24 hours | Beta-cell function index derived from Oral Minimal Model |
| Difference in 24-h glycemia between Meal Conditions and Shift Work | 24 hours | Glucose area under the curve (AUC) based on CGM over 24 hours |
Countries
United States
Contacts
Primary ContactIoannis Lempesis, MD, PhD, PhD
Outcome results
None listed