Tinea Versicolor
Conditions
Brief summary
Pityriasis versicolor (PV) also called tinea versicolor is a common superficial chronic fungal infection of the skin caused by species of lipophilic yeast known as Malassezia species. Itraconazole is an oral synthetic triazole while fluconazole is an oral synthetic bis-triazole compound. Only a few studies are available to find a direct comparison of the efficacy of single dose of oral fluconazole (400 mg) and oral itraconazole (1000 mg) in the treatment of PV. The objective of the study was to compare the efficacy of single dose fluconazole (400 mg stat) to single dose itraconazole (1000 mg stat) in the treatment of pityriasis versicolor in the local population of Pakistan.
Detailed description
Pityriasis versicolor (PV) also called tinea versicolor is a common superficial chronic fungal infection of the skin caused by species of lipophilic yeast known as Malassezia species. Itraconazole is an oral synthetic triazole while fluconazole is an oral synthetic bis-triazole compound. These both acts by inhibiting the cytochrome-P450 dependent 14-alpha-demethylation step in the formation of ergosterol thereby impairing the functions of certain membrane bound enzyme systems, and ultimately inhibiting the growth of fungi. Both the drugs have been studied in different dose regimen, however, there are variable results in studies on this subject. There is still no standard drug and its dosage that can ensure complete cure. Fluconazole (300mg) in 2 doses with an interval of one week has been used effectively, however, fluconazole (400 mg) as a single dose has also been used, and found to cure the PV. Itraconazole 200 mg/day can be given in a dose of for 7 days however, higher concentrations of itraconazole in the stratum corneum are achieved that persist for 3-4 weeks so the drug is presumed to be effective even in a single dose. Therefore, only a few studies are available to find a direct comparison of the efficacy of single dose of oral fluconazole (400 mg) and oral itraconazole (1000 mg) in the treatment of PV. The objective of the study was to compare the efficacy of single dose fluconazole (400 mg stat) to single dose itraconazole (1000 mg stat) in the treatment of pityriasis versicolor in the local population of Pakistan.
Interventions
DRUGFluconazole
400 mg stat. Follow up at 4 weeks
DRUGItraconazole
1000 mg stat. Follow up at 4 weeks
Sponsors
Combined Military Hospital Abbottabad
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 100 Years
Healthy volunteers
Yes
Inclusion criteria
* All the patients above 18 years of age * Diagnosed with pityriasis versicolor
Exclusion criteria
* Those patients who had received any antifungal treatment during last 1 month * pregnancy * lactation * history of renal disease hepatic disease or malignancy * history of hepatic disease * history of malignancy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Clinical Improvement Resolution of symptoms | 4 weeks | Efficacy of treatment was assessed by mycological test by making KOH mount at start of treatment and than at follow up at 4 weeks |
| Efficacy of treatment through KOH mount | 4 weeks | Efficacy of treatment was assessed by mycological test by making KOH mount at start of treatment and than at follow up at 4 weeks |
Countries
Pakistan
Outcome results
None listed