Atrial Fibrillation
Conditions
Brief summary
Our study will include consecutive patients undergoing pulsed field ablation (PFA) or cryoballoon (CBA) ablation. Tissue injury and inflammation markers will be measured before and after the procedure.
Detailed description
Study population: The participants with symptomatic atrial fibrillation scheduled for PFA or CBA procedures Biomarkers of interest: high-sensitive troponin, CRP, NT-proBNP Data collection: Blood samples will be collected at baseline, immediately after the procedure, 24 hours after, and three months after. Statistical analysis: Comparisons of biomarker levels between PFA and CBA groups. Results: Comparison of biomarker levels between PFA and CBA groups at each time point. Changes in biomarker levels over time within each group. Correlation analysis between biomarker levels and clinical outcomes, such as AF recurrence, LA stiffness, complications, and hospitalization.
Interventions
None listed
Sponsors
Ana Jordan
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
* Symptomatic paroxysmal or persistent atrial fibrillation. * Age between 18 and 75 years.
Exclusion criteria
* Prior atrial fibrillation ablation. * History of significant bleeding or thromboembolic events within the last 6 months. * History of severe renal or liver disease. * History of malignancy within the last 5 years. * History of autoimmune disease or immunodeficiency. * Significant mitral stenosis or other significant valvular heart disease. * Pregnancy or breastfeeding.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To see if PFA vs CBA increase left atrium stifness by measuring NT-proBNP values after procedures | One year |
Countries
Croatia
Contacts
Primary ContactAna Jordan
Outcome results
None listed