Postoperative Pain, Acute
Conditions
Brief summary
Patients who undergoing total knee arthroplasty under spinal analgesia will be recruited and randomly assigned to the following two groups according to the regimen of PCA: (A) opioid group who receive only fentanyl citrate 1200mcg for continuous infusion drug, (B) non-opioid group who receive ketorolac tromethamine 150mg with nefopam hydrochloride 100mg for continuous infusion drug. All the patients will receive additional fentanyl citrate as bolus injection drug if they need more analgesics postoperatively.
Interventions
DRUGFentanyl
opioid group receives only fentanyl citrate 1200mcg for continuous infusion drug
DRUGketorolac tromethamine with nefopam hydrochloride
non-opioid group receives ketorolac tromethamine 150mg with nefopam hydrochloride 100mg for continuous infusion drug
Sponsors
Chung-Ang University Gwangmyeong Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
60 Years to 79 Years
Healthy volunteers
No
Inclusion criteria
* ASA physical status I-II * undergoing elective total knee arthroplasty under spinal anesthesia
Exclusion criteria
* history of stomack ulceration * increased ICP * bronchial asthma * allergy on aspirin, NSAIDs, Nefopam * drug user of antiplatelet or anticoagulant
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| postoperative pain score | 24 hours after the surgery | evaluated by visual analogue scale |
Countries
South Korea
Outcome results
None listed