Motor Cortex, Motor Skills
Conditions
Keywords
TMS, Motor system, Healthy
Brief summary
This study aims to evaluate three different transcranial magnetic stimulation protocols and their impact on motor system neurophysiology and skill learning.
Detailed description
Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation method that induces long-term changes in connections between neuronal networks. This and the ability to activate the whole motor system allows the use of TMS to facilitate motor recovery. The motor system has different excitatory states associated with ongoing mu oscillation. Here, the investigators will monitor brain mu oscillations in real-time non-invasively using electroencephalography and modulate the function of the motor system. The investigators will test the impact of three different TMS protocols on motor system neurophysiology and skill learning. These data will provide novel understanding needed to improve TMS approaches for individuals requiring motor rehabilitation.
Interventions
DEVICETranscranial Magnetic Stimulation (TMS)
Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation method that can induce long-term changes in connections between neuronal networks.
Sponsors
Elisa Kallioniemi
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
* 18-40 years old * Able to read, understand, and sign the informed consent in English * Right-handed
Exclusion criteria
* A sensory or physical impairment * History of epilepsy or seizures in the family * Non-removable metal or electronics (e.g., a cochlear implant, cardiac pacemaker, or implanted electronic devices) in your head or body * A head injury with loss of consciousness * Diagnosis of psychiatric or neurological disorder * Skin defects or active infections on the scalp or hands * Pregnancy or breastfeeding
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Effect of TMS on motor evoked potentials | Up to 1 second after TMS | Amplitude of the motor evoked potentials in millivolts. |
| Skill learning accuracy | Up to 12 minutes | Skill learning accuracy as the total number of correct responses. |
| Skill learning speed | Up to 12 minutes | Skill learning speed in seconds. |
Contacts
PRINCIPAL_INVESTIGATORElisa Kallioniemi, Ph.D.
New Jersey Institute of Technology
Outcome results
None listed