Acne Atrophica
Conditions
Keywords
Acne Scar, Dezocine, Pain Relief, Fractional CO2 Laser
Brief summary
The Efficacy and Safety of Dezocine Pretreatment for Pain Relief in Acne Scar Treatment of Fractional CO2 Laser
Interventions
DEVICEFractional CO2 laser
All patients were given oral administration of 0.5mg paronosetron hydrochloride and lidocaine cream 1 hour before surgery. After cleaning and disinfection, fractional CO2 laser treatment was given. Among them, the fractional CO2 laser laser (American Medical Laser company) selected relatively constant energy parameters in the treatment
DRUGDezocine
Desocine injection was injected intravenously half an hour before surgery (10ml normal saline was added for more than 30 seconds)
Sponsors
Xijing Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
No
Inclusion criteria
1. Age: 18-60 years old, regardless of gender; 2. Clinical diagnosis of atrophic acne scars; 3. Planning to undergo ultra-pulsed CO2 lattice laser therapy; 4. The patient agrees to participate in this experiment and signs an informed consent form
Exclusion criteria
1. Those who take sedative drugs for a long time; 2. Patients with sleep apnea syndrome, previous history of hypertension, and blood pressure greater than 160/100mmHg 3. People with severe heart and lung diseases, liver and kidney diseases, psychosis, pregnancy, and communication disorders; 4. Persons who are known to be allergic to the main drug or any of the excipients in Dezocine injection; 5. Increased intracranial pressure or head injury; 6. Acute and chronic alcoholism; 7. People with hypotension, hypothyroidism, acute episodes of asthma, and epilepsy \-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Visual Analog Score for Pain | 24 hours | 0 was classified as painless and 10 was classified as unbearable pain. Marks were made on the corresponding parts of the ruler and scores were scored according to the degree of patient's feeling |
| Hemodynamic parameters | 24 hours | diastolic blood pressure (DBP), systolic blood pressure (SBP) |
| Heart rate (HR) | 24 hours | Hemodynamic parameters |
| oxygen saturation (SpO2) | 24 hours | Hemodynamic parameters |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Occurrence of Adverse Reactions | 24 hours | Nausea, vomiting，dizziness，respiratory depression |
Countries
China
Contacts
Primary ContactChen Yu, MD
Outcome results
None listed