Muscle Weakness, Muscle; Fatigue, Heart, Older Adults
Conditions
Keywords
Body Composition, Older Adults, Diet, Vegetarian, Meat, Beef, Controlled Feeding, Intervention
Brief summary
The goal of this controlled-feeding cross-over diet intervention is to compare a beef diet to a vegetarian diet on muscle fatigue in older adults. The aims are: AIM 1: To test the hypothesis that muscle fatigue is attenuated in older adults consuming beef compared to older adults consuming a plant-based diet. AIM2: To test the hypothesis that daily beef consumption improves biochemical indicators related to muscle fatigue. Participants will be randomized to consume either a beef-based diet or vegetarian diet under controlled-feeding conditions for 8 weeks. After a 2-week washout period, participants will cross-over to consume either the beef diet or vegetarian diet for 8 weeks. Body composition and functional muscle outcomes will be measured during each 8-week feeding period. Blood samples will also be collected.
Interventions
OTHERBeef Diet
Controlled-Feeding Diet Intervention
OTHERVegetarian Diet
Controlled-Feeding Diet Intervention
Sponsors
Indiana University
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
TREATMENT
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
60 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
* Ages 60-85 years * Ability to eat study diet meals for a total of 16 weeks * Ability to perform sit-to-stand chair and 6-minute walking tests based on results from PAR-Q questionnaire * Ability to provide fasted blood samples * Access to transportation * Willing to abstain from alcohol consumption and/or use illicit drug use for each 8-week intervention period * Ability to consent to participating in this study * English-speaking * Body mass index between 18.5 (normal) and 39.9 (obese) kg/m2 * Minimum total body weight of 110 pounds * Non-anemia hemoglobin values: Females - \>12.0 grams/dL; Men - \>13.0 grams/dL * Able to ambulate without assistance * Physician's clearance for study participation (required prior to baseline testing)
Exclusion criteria
* Inability or refusal to sign the informed consent * Significant orthopedic limitations or other contraindications to exercise * Inability or refusal to perform muscle fatigue tests * Has dietary restrictions that prevent to consumption of beef, soy and/or wheat * Has liver or kidney complications * Live or work \>25 miles from Bloomington study site or does not have transportation to the study site * Anticipate elective surgery during the study period * Diagnosis of progressive neurological disorders, musculoskeletal disorders, osteoarthritis, rheumatoid arthritis * Fracture or serious injury in the last 6 months * Stroke, revascularization, deep vein thrombosis, or pulmonary embolism in the past 12 months * Severe cardiovascular disease, uncontrolled systemic hypertension, chronic pulmonary disease * Plan to move residence or travel out of the local area during the study period * Current use of anti-coagulants (e.g. Coumadin or Warfarin) * Current use of prescription medications that affect heart rate or blood vessel dilation * Psychological or social characteristics that would interfere with their ability to fully participate in the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Adherence to Study Diets | Through study completion, approximately 16 weeks | Participant adherence to the study diets will be evaluated. |
| Change in Sit-to-Stand Chair Test | Weeks 0, 4, 8 | The change in muscle strength observed in each diet condition will be evaluated through the Sit-To-Stand Chair Test. The number of times a participant comes to a full standing position (from a seated position) in 60 seconds will be recorded. |
| Change in 6-minute walk | Weeks 0, 4, 8 | The change in muscle strength observed in each diet condition will be evaluated through the 6-Minute-Walk-Test. The distance walked by a participant during the 6 minute test period will be recorded. |
| Retention of Participants | Through study completion, approximately 16 weeks | The percentage of randomized participants completing the 16-week diet intervention trial. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in Lactate | Weeks 0, 4, 8 | Measures of muscle fatigue will be evaluated through blood biomarkers. |
| Change in Beta-Alanine | Weeks 0, 4, 8 | Measures of muscle fatigue will be evaluated through blood biomarkers. |
| Change in Carnosine | Weeks 0, 4, 8 | Measures of muscle fatigue will be evaluated through blood biomarkers. |
| Change in Amino Acids | Weeks 0, 4, 8 | Measures of muscle fatigue will be evaluated through blood biomarkers. |
Countries
United States
Contacts
Primary ContactCydne A Perry, PhD
Outcome results
None listed