Effects of Probiotics on Streptococcus Mutans ve Lactobacillus Spp

Evaluation of Streptococcus Mutans and Lactobacillus Species Due to Probiotic Use in Oral Flora

Status

Completed

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05859646

Enrollment

Registered

2023-05-16

Start date

2020-01-15

Completion date

2022-05-15

Last updated

2023-05-16

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Probiotics, Streptococcus Mutans, Tooth Decay

Keywords

tooth caries, probiotics, qPCR, Streptococcus mutans, Lactobacillus

Brief summary

To evaluate the change of S. mutans and Lactobacillus spp. counts after all dental treatments were completed under general anesthesia and compare the groups in case of using probiotics and not using probiotics with the time for 6-months follow-up period.

Detailed description

Fifthy-eight pediatric patients without any systemical diseases whose dental treatments were completed under general anesthesia were included in the study. The study was carried out as two-groups; Group A: Patients who started using probiotics after general anesthesia and Group B: Patients who did not use probiotics after general anesthesia. The counts of S. mutans and Lactobacillus spp. were determined by quantitative polymerase chain reaction (qPCR) by analysis of saliva samples taken from all patients on the day before the general anesthesia (T0), at 1-month (T1), 3-month (T2) and 6-month (T3) follow-up periods. The statistical significance level was accepted as p\<0.05.

Interventions

DIETARY_SUPPLEMENTProbiotic use

Probiotics were used for 3 months and all participated patients were followed for 6 months.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

PREVENTION

Masking

SINGLE (Outcomes Assessor)

Masking description

The outcome assessment was performed by a different researcher who was unaware of the group distributions in which patients were included.

Intervention model description

2 separate groups, experimental and control, 6 month follow-up period, randomized distribution

Eligibility

Sex/Gender

ALL

Age

2 Years to 12 Years

Healthy volunteers

Yes

Inclusion criteria

* Every included child had at least 8 tooth with caries.

Exclusion criteria

* Patients who would not be able to give saliva samples due to high anxiety or lack of saliva were not included in this study.

Design outcomes

Primary

Measure	Time frame	Description
S mutans count	6 month	CFU
Lactobacillus spp count	6 month	CFU

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 6, 2026