Cerebral Palsy
Conditions
Keywords
functional training, strength, cardiovascular health, cerebral palsy
Brief summary
The goal of this cross-sectional study is to compare able-bodied peers to adolescents and young adults with cerebral palsy (CP) who have been regularly performing high-intensity functional training for almost two years. The main research question is: is structured, long-term exercise training able to compensate strength and cardiovascular deficits in adolescents with CP compared to able-bodied peers?
Detailed description
The pilot study investigating the effects of a functional exercise training in adolescents and young adults with cerebral palsy (CP) showed increases in strength, power, daily function as well as cardiovascular health. In order to establish the origin of the improvements and its broader effects, we wish to conduct follow-up measurements to the pilot study. These follow-up measurements would establish whether the positive changes in physical performance are due to neural or muscular changes (or both), and shed more light on how therapy should be performed and prescribed in adolescents with CP. Additionally, we wish to measure their aerobic capacity as well as examine their microvascular health. For this cross-sectional analysis, the participants of the CP-FIT Pilot Study who continued to train on a regular basis will be compared to age-matched peers in order to establish whether their strength and fitness deficits compared to peers can be compensated through structured and progressive functional exercise training.
Interventions
OTHERPhysical performance and cardiovascular health measures
* Retinal vessel analysis * Muscle ultrasound * Knee extension * Voluntary activation * spiroergometry
Sponsors
University of Basel
Study design
Observational model
OTHER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
14 Years to 27 Years
Healthy volunteers
Yes
Inclusion criteria
CP Individuals: * Diagnosis of CP. * Between 14 and 26 years of age. * Gross Motor Functional Classification System (GMFCS): I-II. * Cognitive abilities must include: Ability to verbally or non-verbally communicate pain or discomfort; Ability to attend testing and; ability to understand and follow instructions. All included participants are capable of making decisions on their own and no not show any signs of mental or cognitive limitations. Healthy peers: \- Between 14 and 26 years of age.
Exclusion criteria
CP Individuals: * Any surgery or botulinum toxin treatment within 6 months prior to the measurements or scheduled during study period. Other medications can be continued as prescribed by the participants' physician. * Known cardiovascular or pulmonary diseases that have not received medical clearance to participate in physical exercise. * Uncontrolled seizures or epilepsy. * Inability to conform to the above mentioned cognitive and physical abilities. Healthy peers: * Diagnosis of congenital heart defects, pulmonary diseases or any neuromuscular disorders or diseases. * Diagnosis of any acute diseases.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Maximum knee extension force | 20 minutes | Maximum force of knee extension in relation to body weight |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Microvascular health | 5 minutes | Static retinal vessel analysis |
| Voluntary activation | 15 minutes | Maximum force able to voluntarily activate |
| Spiroergometry | 20 minutes | Cardiopulmonary test on bicycle ergometer |
| Muscle architecture | 10 minutes | Ultrasound of defined muscle groups |
Countries
Switzerland
Outcome results
None listed