Psychosis
Conditions
Keywords
Cognitive impairment, Transcranial Magnetic Stimulation, Attention, Short-term memory
Brief summary
The main goal of this study is to investigate the neural mechanisms of working memory function in patients with early psychosis using Transcranial Magnetic Stimulation (TMS) in conjunction with functional MRI. TMS is a noninvasive method used to modulate brain activity via changing magnetic fields applied over the surface of the scalp.
Interventions
DEVICEActive TMS
Continuous theta burst stimulation (cTBS) will be administered over the left inferior parietal lobule for approximately 3 minutes at 120% of the resting motor threshold.
DEVICEPlacebo TMS
Placebo TMS will be applied over the left inferior parietal lobule for approximately 3 minutes.
Sponsors
Massachusetts General Hospital
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 35 Years
Healthy volunteers
No
Inclusion criteria
* Diagnosis of psychosis, psychosis not otherwise specified, schizophrenia, schizoaffective disorder, delusional disorder, bipolar disorder with psychosis, and schizophreniform disorder within first ten years of onset of psychotic symptoms. * Ability to provide informed consent
Exclusion criteria
* TMS incompatibility including metallic implants in head and neck, cardiac pacemakers, history of seizures, pregnancy. * MRI-incompatibility including implanted aneurism clips, cardiac pacemakers, metal implants, intrauterine devices, tattoos containing metal ink, pregnancy, and claustrophobia * Severe substance abuse within 3 months (nicotine allowed) * Unstable medical or neurologic illness that would preclude participation in study procedures
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Working memory accuracy | 2 hours | Accuracy at high memory loads during performance of the Sternberg Item Recognition Paradigm will be assessed before and after the TMS interventions. |
| Reaction time during working memory | 2 hours | Reaction time during performance of the Sternberg Item Recognition Paradigm will be assessed before and after the TMS interventions. |
| Resting state functional connectivity between the left inferior parietal lobule and the regions of the frontoparietal control network | 2 hours | Functional connectivity between left inferior parietal lobule and dorsolateral prefrontal cortex will be computed during resting state acquired before and after the TMS interventions. |
| Resting state functional connectivity within the default mode network | 2 hours | Functional connectivity between left inferior parietal lobule and other regions of the default mode network (including the posterior cingulate cortex and the medial prefrontal cortex) will be computed during resting state acquired before and after the TMS interventions. |
Countries
United States
Outcome results
None listed