Myopia, Optical Coherence Tomography, Refractive Errors
Conditions
Brief summary
Corrective eye surgeries, such as Lasik, are widely used to correct focusing problems such as myopia, or nearsightedness. Often these patients develop other conditions like myopic maculopathy or glaucoma which require monitoring with optical coherence tomography (OCT). Since OCT is a light-based test and changes the refractive status of the eye (in the cornea or the lens), it can potentially affect the results of the OCT measurements but has not been sufficiently studied. This pilot study aims at studying the potential change in OCT parameters in the eye after undergoing such surgery.
Detailed description
Refractive surgeries are widely used in patients with ametropia. Refractive surgery is most commonly performed in patients with myopia. These patients often have a predilection for developing other conditions in the posterior segment of the eye, like myopic maculopathy or glaucoma which require monitoring with optical coherence tomography (OCT). Since OCT is a light-based test and changes in the refractive status of the eye (in the cornea or the lens) can potentially affect the results of the OCT measurements. Literature review reveals that the effect of significant changes in refractive power of the eye on the parameters of optical coherence tomography (OCT) has not been sufficiently studied. Some authors simulated the effect of refractive surgery using a contact lens but had diverging results. This prospective pilot study aims at studying the potential change in OCT parameters in the eye after undergoing refractive surgery.
Interventions
DIAGNOSTIC_TESTOptical coherence tomography
Posterior segment OCT (a non-contact procedure performed over one minute) is additionally performed for patients participating in this study. Proportion of change in measurements in microns will be analyzed.
Sponsors
University of Nebraska
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
19 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Patients undergoing refractive surgery 2. For patients undergoing bilateral eye surgery, the one with higher degree of ametropia will be included.
Exclusion criteria
1. Astigmatism more than 3 Diopters 2. Visual acuity worse than 20/25 3. Patients with unstable visual fixation 4. Severe Dry Eye
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Macular thickness | 1 day after refractive procedure | Proportion of Change in thickness of retina and its layers measured in microns |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Choroidal thickness | 1 day after refractive procedure | Proportion of Change in thickness of choroid and its layers measured in microns |
| visual acuity | 1 day after refractive procedure | Proportion of Change in clarity of vision, measured in logarithm of Minimal Angle of Resolution (logMAR) units |
| central corneal thickness | 1 day after refractive procedure | Proportion of Change in thickness of cornea measured in microns |
| anterior chamber depth | 1 day after refractive procedure | Proportion of Change in depth of anterior chamber of the eye measured in microns |
| keratometry | 1 day after refractive procedure | Proportion of Change in corneal curvature measured in diopters |
Countries
United States
Contacts
CONTACTPukhraj P Rishi, MBBS
CONTACTLisa Reid
PRINCIPAL_INVESTIGATORPukhraj P Rishi, MBBS
University of Nebraska
Outcome results
None listed