Respiratory Function Loss, Respiratory Complication
Conditions
Keywords
elastography, ultrasound
Brief summary
The purpose of this study is to evaluate opioid dose effects on the ability of the diaphragm muscle to generate higher force behaviors.
Interventions
Three different fentanyl doses (used for sedation) will be evaluated on their effects on shear wave elastography (SWE) and breathing
Sponsors
Mayo Clinic
National Institute on Drug Abuse (NIDA)
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
TRIPLE (Subject, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
\- Adult male and female patients undergoing lower extremity orthopedic surgery at the study institutions (St. Mary Hospital and Rochester Methodist Hospital within the Mayo Clinic Rochester hospital system).
Exclusion criteria
* Patients who refuse research participation. * Patients who are pregnant. * Patients with known pulmonary pathology (COPD, asthma requiring routine treatment).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Young's modulus (derived from shear wave speed) | Baseline, 10 min post-opioid | Measured by the ultrasound elastography of the diaphragm muscle reported in KPa |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORCarlos Mantilla, MD, PhD
Mayo Clinic
Outcome results
None listed