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A Comparative Clinical Evaluation of the Efficacy of Topical Adapalene, Benzoyl Peroxide Gel, Oral Lactobacillus Rhamnosus, D-chiro-inositol, Inulin Capsule, and Their Fixed Combination in Mild to Moderate Acne Vulgaris Patients.

A Comparative Clinical Evaluation of the Efficacy of Topical Adapalene, Benzoyl Peroxide Gel, Oral Lactobacillus Rhamnosus, D-chiro-inositol, Inulin Capsule, and Their Fixed Combination in Mild to Moderate Acne Vulgaris Patients.

Status
UNKNOWN
Phases
NA
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT05855629
Enrollment
59
Registered
2023-05-11
Start date
2022-02-18
Completion date
2023-07-30
Last updated
2023-05-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acne Vulgaris

Brief summary

The study aims to conduct a comparative clinical evaluation of the effectiveness of a fixed topical combination of adapalene with benzoyl peroxide in the form of a gel, a fixed combination of Lactobacillus rhamnosus, D-chiro-inositol and inulin in the form of capsules and their combination in patients with acne vulgaris of mild and moderate severity and laboratory lipid analysis profile of sebum, lipid metabolism, and IGF-1 (insulin-like growth factor).

Interventions

DIETARY_SUPPLEMENTOral Lactobacillus Rhamnosus, D-chiro-inositol, Inulin Capsule

Lactobacillus Rhamnosus 1,5 х 10\*9, Inulin 25mg, D-chiro-inositol 250mg

DRUGTopical Adapalene, Benzoyl Peroxide Gel

Adapalene 1mg/g, Benzoyl Peroxide 25mg/ml

Sponsors

delta medical promotions ag
CollaboratorUNKNOWN
Treatment and Diagnostic Center of Private Enterprise Asklepiy
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
18 Years to 27 Years
Healthy volunteers
Yes

Inclusion criteria

* Patients with mild to moderate level of Acne Vulgaris

Exclusion criteria

* Pregnancy

Design outcomes

Primary

MeasureTime frameDescription
GAGS (Global Acne Grading System)180 daysThe primary end point of the study is the intensity of acne manifestations according to the GAGS scale

Secondary

MeasureTime frameDescription
IGA (Investigator Global Assessment)180 daysThe secondary end point of the study is the intensity of acne manifestations according to the IGA scale

Countries

Ukraine

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026