Opioid-Induced Esophageal Dysfunction
Conditions
Brief summary
The purpose of this study is to evaluate the effect of opioid cessation on opioid-induced esophageal dysfunction (OIED).
Interventions
BEHAVIORALOpioid cessation
opioid cessation will occur during pain rehabilitative program over approximately 3 weeks
OTHERNo opioid cessation
Subjects will not stop taking opioids
Sponsors
Mayo Clinic
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
\- Patients enrolled in the Pain Rehabilitation Center for opioid cessation, with or without esophageal symptoms.
Exclusion criteria
* Inability to provide informed consent. * Patients with previous gastroesophageal surgery or pneumatic dilation. * Esophageal botulinum toxin injection within the prior 12 months. * Esophageal stricture * Achalasia types I and II * Allergy to Lidocaine or other local anesthetics * Subjects on anticoagulation * Bilateral nasal obstruction * Pregnancy or breast feeding
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number of subjects to have opioid-induced esophageal dysfunction resolution | 4 weeks | Number of subjects to have resolution of opioid-induced esophageal dysfunction |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Number of subjects with dysphagia | 4 weeks | Number of subjects that are chronic opioid users presenting to an opioid cessation clinic to have dysphagia |
| Number of subjects with chest pain | 4 weeks | Number of subjects that are chronic opioid users presenting to an opioid cessation clinic to have chest pain |
| Number of subjects with opioid-induced esophageal dysfunction | 4 weeks | Number of subjects that are chronic opioid users presenting to an opioid cessation clinic to have opioid-induced esophageal dysfunction |
Countries
United States
Contacts
Primary ContactMariah Robran
Outcome results
None listed