Eye Diseases, Vision Impairment
Conditions
Keywords
older adults, eye health, cohort, risk factor, eye diseases
Brief summary
The Proactive Ophthalmic Examination Cohort of Older Adults is a prospective cohort study recruiting community-dwelling older adults aged 65 years or older. Through comprehensive assessment of demographic profiles, medical histories, and ocular structural and functional parameters, alongside systematic collection of ophthalmic and systemic clinical data and biological specimens, we will establish a multidimensional, high-quality ocular health database encompassing demographic characteristics, socioeconomic factors, lifestyle variables, ocular disease risk factors, subjective ocular symptoms, objective examination findings, and biospecimens. The study will investigate the onset and progression patterns of ocular diseases, associated risk factors, and mechanisms of ocular aging in older populations, while simultaneously providing normal-controlled clinical and genomic data for other clinical studies on eye diseases. Furthermore, leveraging algorithmic innovation and artificial intelligence technologies, we will develop a personalized risk prediction and monitoring platform for age-related eye diseases, enhancing early screening and diagnostic capabilities and advancing precision medicine for ocular health in older adults.
Interventions
None listed
Sponsors
Zhongshan Ophthalmic Center, Sun Yat-sen University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
65 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
\- Aged 65 years or older
Exclusion criteria
* Unable to complete required systemic or ophthalmic examinations due to frailty, poor general health, or other physical limitations * Refusal to participate in the study
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Incidence of Visual Impairment | Year 1, Year 2, Year 3, Year 4, Year 5, Year 6, Year 7, Year 8, Year 9, and Year 10 | Visual impairment is defined as best-corrected visual acuity (BCVA) worse than 20/40 in either eye, assessed using a standardized Early Treatment Diabetic Retinopathy Study (ETDRS) chart at each annual visit. Incidence is calculated as the number of new cases per 100 person-years among participants free of visual impairment at baseline. chart at each visit. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change from Baseline in Best-Corrected Visual Acuity (BCVA) | Year 1, Year 2, Year 3, Year 4, Year 5, Year 6, Year 7, Year 8, Year 9, and Year 10 | Best-corrected visual acuity (BCVA) is measured using a standardized Early Treatment Diabetic Retinopathy Study (ETDRS) chart at each annual visit. Change is calculated as the difference between each follow-up measurement and the baseline value obtained at enrollment. |
| Incidence of Age-Related Cataract | Year 1, Year 2, Year 3, Year 4, Year 5, Year 6, Year 7, Year 8, Year 9, and Year 10 | Incidence of age-related cataract, defined as the presence of lens opacity in one or both eyes, was graded using the Lens Opacities Classification System III (LOCS III). New cases are identified among participants who are free of cataract at baseline. |
| Incidence of Age-Related Macular Degeneration (AMD) | Year 1, Year 2, Year 3, Year 4, Year 5, Year 6, Year 7, Year 8, Year 9, and Year 10 | Incidence of AMD, defined as the new development of AMD in one or both eyes, was assessed by fundus photography and optical coherence tomography (OCT) at each annual visit. |
| Incidence of Diabetic Retinopathy (DR) | Year 1, Year 2, Year 3, Year 4, Year 5, Year 6, Year 7, Year 8, Year 9, and Year 10 | Incident diabetic retinopathy is defined among participants with diabetes mellitus and no diabetic retinopathy at baseline as the first detection of any definite diabetic retinopathy, indicated by an Early Treatment Diabetic Retinopathy Study (ETDRS) Diabetic Retinopathy Severity Scale level ≥20 in either eye on standardized annual fundus photography. |
| Incidence of Myopia-Related Fundus Changes | Year 1, Year 2, Year 3, Year 4, Year 5, Year 6, Year 7, Year 8, Year 9, and Year 10 | Incident myopia-related fundus changes are defined among highly myopic eyes without the specified fundus changes at baseline as the first detection during follow-up of lacquer cracks, myopic choroidal neovascularization, patchy chorioretinal atrophy, or macular atrophy, identified by standardized fundus photography and optical coherence tomography (OCT) at annual visits. High myopia was defined as an axial length ≥26.0 mm or spherical equivalent ≤-6.00 diopters at baseline. |
| Change from Baseline in Montreal Cognitive Assessment (MoCA) Score | Year 1, Year 2, Year 3, Year 4, Year 5, Year 6, Year 7, Year 8, Year 9, and Year 10 | Global cognitive function is assessed using the Montreal Cognitive Assessment (MoCA), a validated screening tool covering visuospatial/executive function, naming, memory, attention, language, abstraction, and orientation. Change is calculated as the difference between each annual follow-up score and the baseline score obtained at enrollment. |
| Proportion of Participants Reporting Visual Disturbances | Baseline, Year 1, Year 2, Year 3, Year 4, Year 5, Year 6, Year 7, Year 8, Year 9, and Year 10 | The proportion of participants reporting visual disturbances, including but not limited to photopsia, floaters, diplopia, and metamorphopsia, is collected via a standardized structured questionnaire at each annual visit. |
Countries
China
Contacts
CONTACTHaotian Lin, M.D., Ph.D.
CONTACTXun Wang, M.D.
Outcome results
None listed