Cirrhotic Patients With Spontaneous Bacterial Peritonitis
Conditions
Brief summary
Spontaneous bacterial peritonitis (SBP) is a serious complication of ascites that can lead to death and can be described as an acute infection of ascites without any certain source of infection SBP is considered the most common infection in cirrhotic patients with ascites. SBP is diagnosed by the presence of ≥250 polymorphonuclear leukocyte (PMNL)/mm3 in the ascetic fluid in absence of surgical and treatable causes of intra-abdominal infections . SBP has many pictures of clinical presentation SBP can be asymptomatic and patients pass unnoticed or can discovered accidentally may have local symptoms and signs of peritonitis such as abdominal pain, and tachypnea or may present with signs of deteriorated liver function in form of gastrointestinal bleeding, shock and renal failure An increasing amount of studies have demonstrated that peripheral blood neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR) are indicators of systematic inflammatory response and are widely investigated as useful predictors of the clinical outcomes in various diseases .
Interventions
DIAGNOSTIC_TESTascetic fluid study
ascetic fluid study parameter in diagnosis of spontaneous bacterial peritpnitis
Sponsors
Sohag University
Study design
Observational model
CASE_CONTROL
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
15 Years to 100 Years
Healthy volunteers
No
Inclusion criteria
* Cirrhotic patient with ascites. * Un treated SBP
Exclusion criteria
* Ascites without cirrhosis (malignant ascites, chylous ascites, etc…). * Tuberculous peritonitis. * Secondary bacterial peritonitis due to any surgical cause. * Sepsis rather than SBP. * Patients with unrelated infections e.g. skin, chest infection, etc. * Patients started treatment of SBP. * Patients on prophylactic antibiotics for recurrent SBP prevention . * Patients declining to provide informed consent. * Patients with hepatocellular carcinoma on top of cirrhosis. * Patients with other malignancy or any immunological disease
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Platelets to Lymphocytes Ratio and Monocytes to Lymphocytes Ratio as Predictors of Response to Treatment in Cirrhotic Patients with Spontaneous Bacterial Peritonitis | 19/4/2023 - 30/4/2024 | Spontaneous bacterial peritonitis (SBP) is a serious complication of ascites that can lead to death and can be described as an acute infection of ascites without any certain source of infection SBP is considered the most common infection in cirrhotic patients with ascites. SBP is diagnosed by the presence of ≥250 polymorphonuclear leukocyte (PMNL)/mm3 in the ascetic fluid in absence of surgical and treatable causes of intra-abdominal infections SBP has many pictures of clinical presentation SBP can be asymptomatic and patients pass unnoticed or can discovered accidentally may have local symptoms and signs of peritonitis such as abdominal pain, and tachypnea or may present with signs of deteriorated liver function in form of gastrointestinal bleeding, shock and renal failure |
Countries
Egypt
Contacts
Primary ContactMohamed H Mohamed, resident
Backup ContactAsmaa N Mohamed
Outcome results
None listed