Lung Neoplasms
Conditions
Keywords
Double-lumen Endotracheal Intubation
Brief summary
The goal of this clinical trial is to test the effect of nebulized lidocaine on the hemodynamic response in the participant undergoing double-lumen endotracheal intubation. The main question it aims to answer is to evaluate the changes in mean arterial pressure after intubation. Participants will inhale 5ml of 2% lidocaine by nebulization15min before intubation. Researchers will compare saline group to see if saline effects
Interventions
DRUGLidocaine
inhale 5ml of 2% lidocaine by nebulization
DRUGSaline
inhale 5ml of saline by nebulization
Sponsors
RenJi Hospital
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
1. aged 18-65 years, American Society of Anesthesiologists class I-II 2. participants undergoing double-lumen endotracheal intubation under general anesthesia 3. signed informed consent and volunteered to participate in the experiment
Exclusion criteria
1. Poor control of hypertension 2. preoperative arrhythmia 3. severe coronary artery or heart valve disease 4. sequelae of cerebrovascular accident 5. severe lung, liver, kidney and immune system diseases 6. Suspected difficult airway 7. confirmed or suspected allergy to this trial drug 8. As judged by the investigator to be ineligible for the study, such as communication impairment (language or intelligence)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| mean arterial pressure after intubation | Immediately after intubation |
Contacts
Primary ContactHao Zhu
Outcome results
None listed