Healthy
Conditions
Brief summary
Co-ingesting protein with carbohydrate is an effective way to improve postprandial glucose handling. The investigators have isolated and identified a bioactive protein extracted from seaweed. The investigators aim to explore how varying doses of seaweed protein influence postprandial glycaemia and insulinaemia in a healthy population.
Interventions
DIETARY_SUPPLEMENTSeaweed protein
Novel protein extracted from seaweed
Sponsors
University of Limerick
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
BASIC_SCIENCE
Masking
DOUBLE (Subject, Investigator)
Intervention model description
A three arm, acute randomised, double blind crossover design feeding study will be used to establish the impact and dose response to co-ingestion of BioDulse (a protein hydrolysate from Irish seaweed) with maltodextrin on postprandial blood glucose and insulin concentrations.
Eligibility
Sex/Gender
ALL
Age
18 Years to 67 Years
Healthy volunteers
Yes
Inclusion criteria
* Aged 18-67
Exclusion criteria
* Terminal disease * Past medical history of vascular disease, cancer, diabetes, neurological, kidney, pulmonary, digestive (Coeliac disease), thyroidal disease, cognitive impairment; * Exclusively receiving enteral or parenteral nutrition, * Any conditions/anomalies that are contraindications to bioelectrical impedance analysis as per institutional risk assessment and SOP.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Postprandial blood glucose area under the curve (AUC) | 120 min | Integrated area under curve of blood glucose concentration (measured as mmol/L) over 120min |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Timecourse of blood glucose concentration | 0, 15, 30, 45, 60, 90, 120 min | Timecourse of blood glucose concentration (measured as mmol/L) |
| Postprandial serum insulin area under the curve (AUC) | 120 min | Integrated area under curve of blood glucose concentration (measured as mU/L) over 120min |
| Postprandial serum insulin concentration | 0, 15, 30, 45, 60, 90, 120 min | Timecourse of serum insulin concentration (measured as mU/L) |
Countries
Ireland
Outcome results
None listed