Depression, LPS, Mood
Conditions
Brief summary
This is a randomized controlled trial to examine the effect of anaerobic activity (e.g., weight training) on gut microbiome metabolism and neurological health in healthy sedentary men.
Detailed description
The human gut microbiome, which houses over 2,000 distinct bacterial species, has recently been characterized as a highly influential force on the health and longevity of its host. By way of several distinct pathways comprising the microbiome-gut-brain axis, this diverse population is known to communicate with the human brain in a bidirectional manner and is implicated in the pathophysiology of several metabolic and psychological disease states. The ability to support a healthy, diverse microbiome through modifiable behavioral interventions - such as diet and exercise - is a topic of growing interest. Most of the evidence pertaining to the relationship between physical activity and the gut-brain axis at this time, however, investigates the influence of aerobic exercise providing limited insight to how other modalities of physical activity may differ. Specifically, this study will examine the impact of an 8-week weight training protocol on gut microbiome metabolism and neurological health in healthy sedentary men. Participants will be randomly assigned to the intervention group or the waitlist control group.
Interventions
OTHERweight training
weight training
Sponsors
Arizona State University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE
Intervention model description
randomized controlled trial (waitlist control)
Eligibility
Sex/Gender
MALE
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* free of any existing medical diagnoses * willing and able to participate in moderate to vigorous exercise as determined by the ACSM Health/Fitness Facility Preparticipation Screening Questionnaire * sedentary (defined as a score \<14 on the Godin-Shepard Leisure Time Physical Activity Questionnaire (GSLTQ)) * equipped with access to a complete gym
Exclusion criteria
* antibiotic use within the past six months * prebiotic, probiotic, or high-dose antioxidant supplementation within the past 6 months * smoker (cigarettes and/or marijuana) * regular laxative use * blood pressure \>129/80 at baseline
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| gut barrier integrity | change from baseline at week 8 | serum LPS binding protein |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| mood state | change from baseline at week 8 | Depression score on Center for Epidemiological Studies-Depression (CES-D) questionnaire. Scores range from 0-60, with scores \>15 indicating an elevated risk of depression and scores \>30 indicating elevated symptoms of depression that may influence the health of the individual |
Other
| Measure | Time frame | Description |
|---|---|---|
| anaerobic capacity | change from baseline at week 8 | wingate test |
Countries
United States
Outcome results
None listed