Asthma in Children
Conditions
Brief summary
In this Study i'll compare the effectiveness of two drugs used in acute exacerbation of asthma by their sideffects, complaince and improvement in the PRAM score. The better one would be adapted in our clinical practice.
Interventions
DRUGDexamethasone
Oral Dexamethasone a longer and potent corticosteroid with lesser sideffects and good compliance
DRUGPrednisolone
Oral Multidose Prednisolone
Sponsors
DR. MOHAMMAD ALI ARIF
Study design
Allocation
RANDOMIZED
Intervention model
FACTORIAL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
2 Years to 12 Years
Healthy volunteers
No
Inclusion criteria
* i.Ages 2 to 12years ii. Previous history of asthma as diagnosed by a physician. iii. Presentation with acute exacerbation of asthma with symptoms of cough, wheeze, dyspnoea and oxygen saturation of less than 95% and with PRAM score of more than or equal to 6
Exclusion criteria
* i.Critical or life-threatening asthma i.e. patient with silent chest, cyanosis, drowsy, unable to verbalize, marked tachycardia and respiratory distress. ii.Known TB exposure iii.Fever more than 39. 5°C iv.Use of corticosteroids in previous 4 weeks v.Significant co-morbid disease: lung, cardiac, immune, liver, endocrine, neurological or psychiatric
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Improvement in PRAM score | 4 days | PRAM will be evaluated at day 4 |
Countries
Pakistan
Outcome results
None listed