Memory, Episodic
Conditions
Keywords
memory, Transcranial magnetic brain stimulation, emotional valence
Brief summary
A pilot study, examining the effect of repeated transcranial magnetic brain stimulation (rTMS) on the formation of memories with negative valence. The investigators hypothesize that an effective rTMS protocol to reduce memory performance for adverse events can be found.
Interventions
DEVICErTMS (cTBS 50Hz experiment)
rTMS using cTBS protocol with the following characteristics: * Frequency: trains of 50 Hz (3 pulses) every 200ms (frequency of 5 Hz, in the range of theta band) * Intensity: 80% of resting motor threshold (rMT) * Location: consecutively on the left and right temporo-occipital cortex (MNI coordinates: left hemisphere: -50, -72, 4; right hemisphere:50, -66, 0) * Duration: 40 seconds for each hemisphere, 80 seconds in total. * Timing: Immediately before viewing pictures in pictorial memory task (off-line)
DEVICErTMS (cTBS sham)
rTMS using cTBS protocol with the following characteristics: * Frequency: trains of 50 Hz (3 pulses) every 200ms (frequency of 5 Hz, in the range of theta band) * Intensity: 0% * Location: consecutively on the left and right temporo-occipital cortex (MNI coordinates: left hemisphere: -50, -72, 4; right hemisphere:50, -66, 0) * Duration: 40 seconds for each hemisphere, 80 seconds in total. * Timing: Immediately before viewing pictures in pictorial memory task (off-line)
DEVICErTMS (cTBS 50 Hz active control)
rTMS using cTBS protocol with the following characteristics: * Frequency: trains of 50 Hz (3 pulses) every 200ms (frequency of 5 Hz, in the range of theta band) * Intensity: 80% of resting motor threshold (rMT) * Location: Right superior frontal cortex * Duration: 40 seconds for each hemisphere, 80 seconds in total. * Timing: Immediately before viewing pictures in pictorial memory task (off-line)
DEVICErTMS (high frequency)
rTMS using high frequency protocol with the following characteristics: * Frequency: 20 Hz * Intensity: 120% of rMT for rMT \< 54% & 65% of MSO for rMT ≥ 54% * Location: temporo-occipital cortex of the dominant brain hemisphere * Duration: 20 minutes, continuously * Timing: During the pictorial memory task (on-line) 1 second stimulation and 14 seconds inter-train interval for 76 trains resulting in a total of 1520 pulses.
DEVICErTMS (low frequency)
rTMS using Low frequency protocol with the following characteristics: * Frequency: 1 Hz * Intensity: 110% of rMT * Location: temporo-occipital cortex of dominant brain hemisphere (MNI left hemisphere: -50, -72, 4; right hemisphere:50, -66, 0) * Duration: 30 minutes, continuously * Timing: Starting 10 minutes before and continuing during the picture viewing and valence rating of the pictures of the memory task (on-line).
DEVICErTMS (high frequency sham)
* Frequency: 20 Hz * Intensity: 10% of MSO * Location: temporo-occipital cortex of the dominant brain hemisphere * Duration: 20 minutes, continuously * Timing: During the pictorial memory task (on-line) 1 second stimulation and 14 seconds inter-train interval for 76 trains resulting in a total of 1520 pulses.
DEVICErTMS (high frequency active control)
* Frequency: 20 Hz * Intensity: 120% of rMT for rMT \< 54% & 65% of MSO for rMT ≥ 54% * Location: right superior frontal cortex of the dominant brain hemisphere * Duration: 20 minutes, continuously * Timing: During the pictorial memory task (on-line) 1 second stimulation and 14 seconds inter-train interval for 76 trains resulting in a total of 1520 pulses.
DEVICErTMS (low frequency active control )
* Frequency: 1 Hz * Intensity: 110% of rMT * Location: Right superior frontal cortex of the dominant brain hemisphere * Duration: 6 minutes * Timing: Starting 1 minutes before and continuing during the memory task (Online)
DEVICErTMS ( cTBS 30 Hz active control)
* Bilateral continuous theta burst stimulation (cTBS) 30 Hz: * Frequency: trains of 30 Hz (3 pulses) every 167 ms (frequency of 6 Hz, in the range of theta band) * Intensity: 100% of resting motor threshold (rMT) * Location: consecutively on right superior frontal cortex * Duration: 33.3 seconds for each side * Timing: Immediately before pictorial memory task (off-line)
DEVICErTMS (cTBS 30 Hz)
* Bilateral continuous theta burst stimulation (cTBS) 30 Hz: * Frequency: trains of 30 Hz (3 pulses) every 167 ms (frequency of 6 Hz, in the range of theta band) * Intensity: 100% of resting motor threshold (rMT) * Location: consecutively on left and right temporo-occipital cortex * Duration: 33.3 seconds for each side * Timing: Immediately before pictorial memory task (off-line)
Sponsors
Prof. Dominique de Quervain, MD
Study design
Allocation
RANDOMIZED
Intervention model
SEQUENTIAL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 30 Years
Healthy volunteers
Yes
Inclusion criteria
* Male or female * Generally healthy * Normotensive (BP 90/60mmHg - 140/90mmHg) * BMI: 19 - 30 kg/m2 * Age: 18 - 30 years * Fluent German-speaking
Exclusion criteria
* Metal in the brain, skull or elsewhere in the body (e.g., splinters, fragments, clips, etc.) * Implanted neurostimulator (e.g., DBS, epidural/subdural, VNS) * Cardiac pacemaker or intracardiac lines * Medication infusion device * Nonremovable Piercings in the head area, pivot teeth (retainers are no exclusion criterion) * Tattoos (head area) less than 3 months old or older than 20 years * Condition after neurosurgery * Hearing problems or tinnitus * Not able to sit still due to tremor, tics, itching * History of repeated syncope * Head trauma diagnosed as concussion or associated with loss of consciousness * diagnosis of epilepsy, or a convulsion or a seizure in the past of the participant or his/her close family * TMS in the past showing problems * Surgical procedures to spinal cord * Spinal or ventricular derivations * Alcohol or drug intake 48 hours before start of visits * Regular intake of any medication or CNS-active medication 48h before visit * rMT above the limits of rTMS device.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| memory recall performance | On average 1 hour after intervention | The difference between valence specific (negative, positive, and neutral) memory performance as assessed by a standard picture recall episodic memory task. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Working memory performance | On average 1 hour after intervention | Working memory performance measured by n-back task |
Countries
Switzerland
Outcome results
None listed