Phase Locked TRanscranial Electrical EXcitation

T-REEX: Phase Locked TRanscranial Electrical EXcitation

Status

UNKNOWN

Phases

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT05847829

Acronym

T-REEX

Enrollment

Registered

2023-05-08

Start date

2023-06-10

Completion date

2023-11-01

Last updated

2023-09-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Novel Method for Transcranial Brain Stimulation

Keywords

Brain stimulation, Closed-loop, Brain activity

Brief summary

Transcranial current stimulation (tCS) has been extensively studied due to its potential of selectively stimulate brain regions in a non-invasive way. However, classic stimulation paradigms are often applied in an open loop configuration, without considering the effects on the underlying brain activity. Recent studies suggest that when alternating current are used, it would be beneficial to phase lock the stimulation to the target brain wave of interest to achieve selective temporal stimulation, allowing for better control over the stimulation effects. This study aims at demonstrating a novel setup that allows for precise stimulation targeted in space and time. To achieve that, a combination of tCS and (EEG phased locked) closed-loop modality are used to obtain the required selectivity.

Interventions

DEVICET-REEX algorithm

Phase locked transcranial stimulation.

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DEVICE_FEASIBILITY

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

18 Years to 64 Years

Healthy volunteers

Yes

Inclusion criteria

* Signed informed consent * Age between 18 and 64

Exclusion criteria

* Wounded or particular sensitive skin at areas of investigation. For example, skinrash, discoloration, scars, or open wounds * Allergies to adhesive or dry electrodes or silver chloride * Pregnant or lactating * Any of the following symptoms (fever, tiredness, dry cough, aches and pains, nasal congestion, runny nose, sore throat, diarrhoea) * Known neurological disorders * Previous epileptic episodes * Active implants such as pacemakers or brain stimulators * Intracranial metal implants

Design outcomes

Primary

Measure	Time frame
The phase difference (error) between the estimated phase of EEG activity and the phase of the delivered stimulation at the target locationor EEG readout and tCS stimulation	2 hours

Secondary

Measure	Time frame
the amount of phase and/or amplitude change in the brain wave of interest (e.g., 10 Hz alpha activity) resulting from different tCS modalities and stimulation parameters used	2 hours

Countries

Netherlands

Contacts

Primary ContactRaf van Hoof, PhD

HoofR@kempenhaeghe.nl0031 40 227 92 04

Backup ContactHans van Dijk, PhD

DijkH@kempenhaeghe.nl0031 40 227 92 04

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026