Tuberculosis
Conditions
Keywords
Latent Tuberculosis, Healthcare workers, IGRA
Brief summary
Prospective, descriptive study to assess latent tuberculosis infection (LTBI) among healthcare worker (HCW) in a tertiary hospital in a low-risk area.
Detailed description
identification and treatment of LTBI can substantially reduce the risk of development of disease and are important TB control strategies, especially in settings with a low tuberculosis (TB) incidence, where reactivation of LTBI often accounts for the majority of non-imported TB disease treatment of LTBI can substantially reduce the risk of development of disease. In Portugal the real prevalence of LTBI in low-risk HCWs has not been evaluated since they are not included in the periodic screening programs. It is important to diagnose TB infections in HCWs to prevent nosocomial transmission, particularly among immunocompromised patients. The risk for transmission varies by setting, occupational group, local prevalence of TB, patient population, and effectiveness of TB infection control measures. Prevention of active TB disease by treatment of LTBI is a critical component for public health. Tuberculin skin test (TST) is used worldwide to diagnose LTBI, whereas interferon-γ release assay (IGRA) are used in some countries according to their national TB programs. IGRA offers a potential method of serial testing to diagnose LTBI in HCWs, and it has better specificity than that of TST in one-time screening. Study participants should be identified and contacted by occupational health service. In association, study information should be disseminated through posters and institutional email.
Interventions
DIAGNOSTIC_TESTIGRA/Tuberculin skin test
All patients will receive: * Clinical evaluation; * Chest x-ray. * IGRA (or tuberculin skin test if immunocompromised) * Therapeutic proposal if eligible
Sponsors
Centro Hospitalar do Oeste
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* All HCW from our hospital with risk of exposure, working in our hospital for at least 3 consecutive months * Acceptance to participate and signed informed consent form
Exclusion criteria
* History of previous tuberculosis * Active Tuberculosis * Refusal to sign the informed consent form
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Number and percentage of latent tuberculosis diagnosis in healthcare workers | 1 year | Patients with positive IGRA/tuberculin test screening and without clinical or radiological features of active Tuberculosis |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Treatment acceptance for latent tuberculosis | 1 year | Number of positive screening participants who accept and start treatment |
| Treatment completion | 1 year | Number of patients who finished treatment |
Other
| Measure | Time frame | Description |
|---|---|---|
| Treatment discontinuation | 1 year | Number of patients who did not complete treatment |
Countries
Portugal
Contacts
Primary ContactCarina Rolo Silvestre, MD, MSc
Backup ContactRicardo Cordeiro, MD
Outcome results
None listed