Respiratory Failure
Conditions
Brief summary
Ninety adult patients from both gender, with acute respiratory failure, intubated and mechanically ventilated. Their ages ranged from 50 to 70 years. They were selected from Intensive Care Unit (ICU), Department of Chest Diseases, Cairo University Hospitals. They have randomly assigned into three equal groups. Group (A): trained by threshold IMT device plus routine physical therapy. Group (B): trained by adjusting MV trigger sensitivity plus routine physical therapy. Group (C): only received routine physical therapy. (Negative inspiratory force NIF, arterial blood gases, P/F ration, respiratory rate RR, tidal volume VT, and rapid shallow breathing index RSBI) were measured before the study and at the end of the study (just before weaning for successfully weaned patients, or on the 10 day of intervention for failed weaning patients).
Interventions
OTHERThreshold inspiratory muscle trainer device
The threshold inspiratory muscle trainer (IMT) device offers resistance to respiration through the spring-loaded valve.
OTHERAdjusting mechanical ventilator trigger sensitivity
modifying the mechanical ventilator trigger sensitivity so that patients can only initiate inspiratory flow by producing more negative intrathoracic pressure
OTHERChest physiotherapy
Conventional chest physiotherapy
Sponsors
Cairo University
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
50 Years to 70 Years
Healthy volunteers
No
Inclusion criteria
* Their age ranged from 50-70 years. * The patients were diagnosed with acute respiratory failure duo to COPD exacerbation and need mechanical ventilation support for more than 48 hours. * They were vitally stable and can tolerate pressure support * PEEP less than 8Cm H2O , SpO2 more than 90). * All patients were conscious and responded to verbal command.
Exclusion criteria
* Unstable hemodynamics, * unstable neurological problems, * lack of attention and cooperation * skipping more than five training sessions.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| partial pressure of oxygen(PaO2) | change from baseline at one week | arterial blood sample was taken and examined thePao2 |
| partial pressure of carbon dioxide(PaCO2) | change from baseline at one week | arterial blood sample was taken and examined the PaCO2 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Respiratory rate (RR) | change from baseline at one week | Number of respiratory cycles per minute |
| tidal volume (TV) | change from baseline at one week | volume of air inspired in quiet breathing |
Countries
Egypt
Outcome results
None listed