Neurocognitive Disorders, Dementia, Hypertension, Aged, 80 and Over
Conditions
Keywords
Neurocognitive Disorders, Dementia, Hypertension, Aged, 80 and over
Brief summary
Neurocognitive disorders and hypertension occur commonly with aging. While, by definition, older adults are at high cardiovascular risk, there is no guideline exist currently on blood pressure management of elderly hypertension. However, studies have shown that in aging adults, high blood pressure helps prevent against cognitive decline, and low blood pressure on antihypertensive drugs could accelerate it. This study aims at investigating if pharmacological treatment of hypertension in the very elderly is influenced by presence and severity of neurocognitive disorders. Our research hypothesis is that the drug management of hypertension in patients 80 years of age or older more is all the less aggressive as the neurocognitive disorders are advanced.
Interventions
number of hypertensive drugs
Sponsors
Central Hospital, Nancy, France
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
80 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* to be 80 years of age * with history of hypertension and/or on hypertensive drug(s)
Exclusion criteria
* legal protection measure.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| number of antihypertensive agents | during inclusion | among ACEI/ARB2, calcium channel blocker, thiazides and related, central antihypertensive beta blocker |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| class of antihypertensive medications | during inclusion | among ACEI/ARB2, calcium channel blocker, thiazides and related, central antihypertensive beta blocker |
| systolic and diastolic blood pressure | during inclusion | blood pressure measured with upper arm cuffs |
| orthostatic hypotension | during inclusion | a systolic blood pressure decrease of at least 20 mm Hg or a diastolic blood pressure decrease of at least 10 mm Hg within three minutes of standing |
Countries
France
Outcome results
None listed