Unruptured Intracranial Aneurysm
Conditions
Brief summary
The goal of this prospective observational cohort study is to learn about treatment strategies for unruptured intracranial aneurysms in the Chinese population. The main questions it aims to answer are: * To establish a cohort of patients with intracranial unruptured aneurysm and explore the optimal clinical treatment strategy. * To establish clinical management path for patients with unruptured intracranial aneurysm. According to the treatment of all patients with unruptured intracranial aneurysm, they were divided into the following groups: 1. Conservative treatment group; 2. Intracranial aneurysm clipping group; 3. Coil embolization or stent-assisted coil embolization group; 4. Flow diversion group.
Interventions
OTHERobservation
observation
Sponsors
Beijing Tiantan Hospital
Huashan Hospital
The First Affiliated Hospital of Zhengzhou University
First Affiliated Hospital of Fujian Medical University
Shanxi Provincial People's Hospital
Peking University First Hospital
Peking University Third Hospital
Beijing Chao Yang Hospital
Beijing Friendship Hospital
Beijing Hospital
Anhui Provincial Hospital
The First Affiliated Hospital of Anhui Medical University
Binzhou Medical University
The Second Affiliated Hospital of Dalian Medical University
Xijing hospital of The fourth military medical university
Fujian Medical University Union Hospital
The First Dongguan Affiliated Hospital of Guangdong Medical University
First Affiliated Hospital of Guangxi Medical University
The First Affiliated Hospital of Guangzhou Medical University
The second People's Hospital of Guiyang
The Affiliated Hospital Of Guizhou Medical University
Guizhou Provincial People's Hospital
Affiliated hospital of Guilin medical university,China
National Center for Neurological Disorders (China)
First Affiliated Hospital of Harbin Medical University
Changhai Hospital, Naval Medical University
The Second Affiliated Hospital of Hainan Medical University
The Second Hospital of Hebei Medical University
Wuhan TongJi Hospital
Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
The First Hospital of Jilin University
Guangzhou Red Cross Hospital
Jiangnan University Medical Center
Xunxian People's Hospital
The Second Affiliated Hospital of Kunming Medical University
First Affiliated Hospital of Kunming Medical University
Lanzhou University Second Hospital
The Southwest Hospital of Army Medical University
Second Affiliated Hospital of Nanchang University
Nanfang Hospital, Southern Medical University
The General Hospital of Eastern Theater Command
Inner Mongolia People's Hospital
General Hospital of Ningxia Medical University
Qinghai People's Hospital
The First Affiliated Hospital of Xiamen University
Qilu Hospital of Shandong University
Qilu Hospital of Shandong University (Qingdao)
Qingdao Municipal Hospital
The First Affiliated Hospital of Shanxi Medical University
Shanghai Sixth People's Hospital, Affiliated to Shanghai Jiao Tong University
Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
RenJi Hospital
Shenzhen Second People's Hospital
The General Hospital of Northern Theater Command
Xuanwu Hospital, Beijing
West China Hospital
Sichuan Provincial People's Hospital
Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, China
Second Affiliated Hospital of Soochow University
The First Affiliated Hospital of Soochow University
Tangshan Gongren Hospital
Tianjin Huanhu Hospital
Tianjin Medical University General Hospital
First Affiliated Hospital Xi'an Jiaotong University
Second People's Hospital of Tibet Autonomous Region
Tibet Autonomous Region People's Hospital
Second Xiangya Hospital of Central South University
First Affiliated Hospital of Xinjiang Medical University
The Affiliated Hospital of Xuzhou Medical University
School of brain science and brain medicine, Zhejiang University
The Second Affiliated Hospital Zhejiang University School of Medcine
Fifth Affiliated Hospital of Zhengzhou University
Chinese PLA General Hospital
First Affiliated Hospital of China Medical University
Shengjing Hospital
First Affiliated Hospital, Sun Yat-Sen University
Chongqing General Hospital
First Affiliated Hospital of Chongqing Medical University
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
A. age \> 18 years. B. at least one intracranial aneurysm needs to be treated by craniotomy, endovascular treatment or combined surgery. C. patients' consent were obtained.
Exclusion criteria
1. Ruptured intracranial aneurysms, accompanied by subarachnoid hemorrhage or cerebral hemorrhage ; 2. Traumatic, infectious and atrial myxoma-associated intracranial aneurysms ; 3. Combined with cerebrovascular malformations; 4. Combined with brain tumors or malignant tumors in other parts ; 5. Combined with systemic connective tissue disease and systemic rheumatic disease ; 6. Due to other diseases, or poor general condition, the expected survival time is not more than 12 months ; 7. During pregnancy and perinatal period.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Primary Outcome | 2 years | Functional outcomes(modified Rankin Scale,mRS) at 2 years after treatment decision |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| MACCE events | 1 years | Incidence of major adverse cardiovascular/cerebrovascular events (MACCE events) in patients with atherosclerotic heart disease within 1 year after treatment decision. |
| cardiovascular/cerebrovascular events | 2 years | Incidence of cardiovascular/cerebrovascular events in 2 years after receiving different treatment strategies. |
| Cost | 2 years | Costs associated with unruptured intracranial aneurysms within 2 years after treatment with different strategies. |
| Aneurysm-related bleeding events | 2 years | Incidence of aneurysmal-related bleeding events within 2 years after receiving different treatment strategies. |
| Mortality associated with intracranial aneurysms | 2 years | Mortality associated with intracranial aneurysms within 2 years after treatment with different strategies |
| All-cause mortality | 2 years | All-cause mortality of patients within 2 years after different treatment strategies. |
Countries
China
Contacts
STUDY_CHAIRWang shuo, M.D.
Beijing Tiantan Hospital
Outcome results
None listed