NAFLD, PCOS
Conditions
Keywords
polycystic ovary syndrome, non-alcoholic fatty liver disease, obesity, insulin resistance
Brief summary
This study was planned to examine the prevalence of vitamin D insufficiency, insulin resistance, non-alcoholic fatty liver disease (NAFLD), and their relationship with each other and the nutritional status of individuals with polycystic ovary syndrome (PCOS) in reproductive age, by evaluating anthropometric, biochemical, and ultrasonographic findings and food consumption frequency data.
Detailed description
A total of 72 female individuals diagnosed with PCOS were included in the study. Nutritional status, physical activity levels, anthropometric measurements, and biochemical parameters of individuals were examined. A food consumption frequency questionnaire was applied to the individuals. According to the 2003 Rotterdam Consensus revision, PCOS is diagnosed when at least two of the following three conditions are present: Polycystic ovaries on ultrasonography, oligomenorrhoea, or anovulation; clinical and/or biochemical symptoms of hyperandrogenemia. Testing was done on insulin, lipid profiles, fasting plasma glucose, and liver function. Bioelectrical impedance analysis was used to determine body weight and composition. An abdominal ultrasound was used to diagnose NAFLD.
Interventions
OTHERQuestionnaire
Nutritional status, physical activity levels, anthropometric measurements, and biochemical parameters of individuals were examined. A food consumption frequency questionnaire was administered.
Sponsors
Hacettepe University
Study design
Observational model
OTHER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Age
19 Years to 40 Years
Healthy volunteers
No
Inclusion criteria
* female sex * PCOS diagnosis * no use of oral contraceptives or any hormone therapy in the last 3 months * no use of vitamin D supplements in the last 3 months * no use of oral antidiabetic drugs in the last 3 months
Exclusion criteria
* adrenal dysfunction * diabetes mellitus * pregnancy * alcohol consumption * a history of chronic viral hepatitis * autoimmune liver disease * other liver diseases * history of hepatotoxicity * use of antihypertensive, antidiabetic, lipid-lowering drugs
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Serum vitamin D levels | 3 months | Serum vitamin D levels were measured by immunoassay analyzer. |
| Insulin resistance | 3 months | Insulin resistance analyzed by homeostasis model assessment-insulin resistance (HOMA-IR) formulation. |
| Non-alcoholic fatty liver disease (NAFLD) grade | 3 months | NAFLD grade was evaluated by ultrasonography. |
Countries
Turkey (Türkiye)
Outcome results
None listed