OCD
Conditions
Keywords
functional MRI
Brief summary
This study aims to define individual profiles of treatment resistants in order to find indicators and predictors of the therapeutic response.
Interventions
OTHERFunctional MRI
Three cognitive tests will be performed in the MRI, namely a stroop task, an N-back task and a switching task
Sponsors
Centre Hospitalier Henri Laborit
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* Obsessive compulsive disorder diagnosed according to Diagnostic and Statistical Manual 5 criteria (patients will be included regardless of the severity and resistance of their pathology and their levels of executive functions) * Understand and accept the constraints of the study * Be a beneficiary or affiliated to a Health Insurance scheme
Exclusion criteria
* Present one of the diagnoses according to the criteria of the DSM 5: schizophrenic disorders, substance abuse or dependence to a substance according to the criteria of the M.I.N.I. version 5.0 (Sheehan et al., 1998) * Generalized anxiety disorder, social anxiety, nicotine dependence and history of a major depressive episode are not
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Cerebral activity modification during N-back task | Day 1 | Blood-oxygen-level-dependent (BOLD) modification during the task between obsessive compulsive disorder patients and controls |
| Cerebral activity modification during Stroop task | Day 1 | Blood-oxygen-level-dependent (BOLD) modification during the task between obsessive compulsive disorder patients and controls |
| Cerebral activity modification during switching task (Monsell et Mizon task ) | Day 1 | Blood-oxygen-level-dependent (BOLD) modification during the task between obsessive compulsive disorder patients and controls |
Countries
France
Contacts
Primary ContactDamien Doolub, MD
Outcome results
None listed