Association Between Carotid Plaque Length and Cardiovascular Outcomes

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT05843487

Enrollment

3000

Registered

2023-05-06

Start date

2017-01-01

Completion date

2030-12-31

Last updated

2023-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Carotid Plaque, Coronary Artery Disease

Keywords

Carotid Artery Ultrasound, Carotid Plaque, Coronary Artery Disease

Brief summary

This multicenter study involved 5 hospitals (Changhai Hospital; Yueyang Hospital of Shanghai University of Traditional Chinese Medicine; Gongli Hospital; Putuo Hospital of Shanghai University of Traditional Chinese Medicine; No. 904 Hospital of the PLA Joint Logistics Support Force Wuxi). The study enrolled 5000 consecutive patients without known CAD who underwent first coronary angiography for stable chest pain and carotid ultrasound was performed during hospitalization from January 2017 through December 2018.

Detailed description

Patients who had obstructive CAD (defined as ≥50% luminal stenosis) confirmed by coronary angiography and who underwent carotid scanning were included in the final analysis.Carotid ultrasonography was performed simultaneously, and carotid intima-media thickness (IMT), maximum thickness and length of all plaques were measured.The incidence of major adverse cardiovascular events was recorded during follow-up.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients who underwent coronary angiography for stable chest pain and carotid ultrasound simultaneously; * Patients with obstructive CAD (≥50% coronary stenosis);

Exclusion criteria

* \<18 years of age; * previous carotid surgery or significant carotid artery disease; * prior stroke or transient ischemic attack; * previously documented CAD (including history of myocardial infarction, acute coronary syndrome, or coronary revascularization);

Design outcomes

Primary

Measure	Time frame	Description
major adverse cardiovascular events	3 years	cardiovascular death, myocardial infarction, ischemic stroke and coronary revascularization

Secondary

Measure	Time frame
cardiovascular death	3 years
myocardial infarction	3 years
all-cause death	3 years
coronary artery revascularization	3 years
heart failure	3 years
ischemic stroke	3 years

Countries

China

Outcome results